32 citations
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December 2019 in “The Journal of clinical investigation/The journal of clinical investigation” This study found that EGFR and MEK inhibitors may induce acneiform skin toxicities by interacting with the skin bacterium Cutibacterium acnes to increase IL-36γ and IL-8 production in keratinocytes.
1 citations
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February 2020 in “The Journal of clinical investigation/The journal of clinical investigation” This study elucidates a mechanism for acne-like skin toxicity caused by EGFR/MEK inhibitors, involving an interaction with skin bacteria to trigger inflammation, which supports existing antibiotic treatment practices.
19 citations
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October 2008 in “Journal der Deutschen Dermatologischen Gesellschaft” This article reviews the cutaneous reactions and characteristic skin changes associated with chemotherapy, radiation therapy, and new targeted cancer treatments, reporting no new clinical results.
1 citations
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April 2025 in “Clinical Cosmetic and Investigational Dermatology” This study reports two cases of erlotinib-induced erosive pustular dermatosis of the scalp in patients with non-small cell lung cancer, emphasizing the need for dermatological monitoring during EGFR inhibitor therapy.
19 citations
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September 2008 in “Journal of Cellular Physiology” This article explores potential mechanisms of acneiform skin eruptions linked to EGFR inhibition in cancer patients, focusing on EGFR's role in controlling IL-1-dependent inflammation at hair follicles, but reports no clinical results.