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GlossaryCutibacterium acnes

bacteria on skin contributing to acne development

Cutibacterium acnes, formerly known as Propionibacterium acnes, is a type of bacteria commonly found on human skin. It plays a role in the development of acne by contributing to inflammation and infection within hair follicles. While it is a normal part of the skin's microbiome, an overgrowth or imbalance can lead to skin issues.

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research IL-36γ Drives Skin Toxicity Induced by EGFR/MEK Inhibition and Commensal Cutibacterium Acnes

32 citations, December 2019 in “The Journal of clinical investigation/The journal of clinical investigation”

A protein called IL-36γ causes skin side effects from certain cancer treatments when combined with a common skin bacteria.

research Suppression of Cutibacterium Acnes-Mediated Inflammatory Reactions by Fibroblast Growth Factor 21 in Skin

7 citations, March 2022 in “International Journal of Molecular Sciences”

FGF21 can help reduce skin inflammation caused by C. acnes.

research Antibacterial Toner Exhibits Bactericidal Effect Against Cutibacterium Acnes via Keratin and Sebum Plug Penetration

January 2024 in “Journal of Microorganism Control”

The antibacterial toner can effectively kill acne-causing bacteria by penetrating skin plugs.

Short-Chain Fatty Acids from Cutibacterium Acnes Activate Both a Canonical and Epigenetic Inflammatory Response in Human Sebocytes

research Short-Chain Fatty Acids from Cutibacterium Acnes Activate Both a Canonical and Epigenetic Inflammatory Response in Human Sebocytes

70 citations, February 2019 in “The journal of immunology/The Journal of immunology”

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

research TREM2 Macrophages Induced by Human Lipids Drive Inflammation in Acne Lesions

62 citations, July 2022 in “Science Immunology”

TREM2 macrophages and unsaturated lipids contribute to acne inflammation.

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community DHT Harms Scalp Microbiome: DHT Itch is REAL

in Research/Science 407 upvotes 1 month ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.