Host-Microbiome Interactions and Recent Progress in Understanding the Biology of Acne Vulgaris

October 2018 in “ Microbiome ”

Alan M. O’Neill, Richard L. Gallo

acne vulgaris host-microbiome interactions Staphylococcus epidermidis Cutibacterium acnes C. acnes sebum production metagenomic sequencing acne microbiome virulence factors immune system microbiome-based treatments acne skin microbes microbiome

Studysummary This study examined recent findings on the role of host-microbiome interactions in acne, highlighting that the skin's microbiome composition differs between acne-affected and healthy individuals and discussing emerging microbiome-based treatments.

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research Understanding the Role of Propionibacterium Acnes in Acne Vulgaris: The Critical Importance of Skin Sampling Methodologies

59 citations , October 2016 in “Clinics in dermatology”

This review discusses various sampling methods for studying Propionibacterium acnes in skin follicles and reports no new experimental results; the authors evaluate these methods' strengths and limitations.

research Linking Diet to Acne Metabolomics, Inflammation, and Comedogenesis: An Update

138 citations , July 2015 in “Clinical, Cosmetic and Investigational Dermatology”

This review discusses how Western diet may contribute to acne vulgaris through insulin signaling and metabolomic changes, promoting a dietary approach for management, but reports no new experimental results.

research Proteome Analysis of Human Sebaceous Follicle Infundibula Extracted from Healthy and Acne-Affected Skin

62 citations , September 2014 in “PLoS ONE”

This study identified distinct human and bacterial protein profiles in sebaceous follicular casts, with acne samples showing proteins linked to inflammation and normal samples showing proteins involved in stress protection.

research Pattern of Tissue Invasion by Propionibacterium Acnes in Acne Vulgaris

35 citations , March 2012 in “Journal of dermatological science”

This observational study aims to more accurately detect and localize Propionibacterium acnes in acne lesions by combining multiple microbiological visualization techniques, but it does not present new results on their causality to acne.

research Comparison of Artificial Sebum with Human and Hamster Sebum Samples

49 citations , September 2008 in “International journal of pharmaceutics”

This study suggests that artificial sebum L may serve as an effective substitute for human sebum in drug transport studies, due to its similar physicochemical properties.

research Bioengineering a Humanized Acne Microenvironment Model: Proteomics Analysis of Host Responses to Propionibacterium Acnes Infection In Vivo

40 citations , July 2008 in “PROTEOMICS”

This study introduced a bioengineered model that simulates acne's microenvironment in mice, enabling the exploration of host and P. acnes interactions and presenting a novel platform for anti-acne drug and vaccine screening.