Hydra And The Hair Follicle – An Unconventional Comparative Biology Approach To Exploring The Human Holobiont

    March 2022 in “ BioEssays
    Marta B. Lousada, Tim Lachnit, J. Edelkamp, Ralf Paus, Thomas C. G. Bosch
    TLDR Hydra can help understand human hair follicle microbiomes and develop new skin disease therapies.
    The study investigates using Hydra as a model to understand the human hair follicle (HF) microbiome, focusing on host-microbiota interactions, nutrient dependencies, and immune responses. Insights from Hydra, with its simpler microbiome, could inform therapies for HF-related conditions like alopecia by highlighting the role of lipid metabolism, antimicrobial peptides, and immune mechanisms in maintaining microbial balance. The research suggests that understanding these interactions in Hydra could guide therapeutic strategies, including probiotic treatments, to restore microbiome balance in human HFs.
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