Hydra And The Hair Follicle – An Unconventional Comparative Biology Approach To Exploring The Human Holobiont

    March 2022 in “ BioEssays
    Marta B. Lousada, Tim Lachnit, J. Edelkamp, Ralf Paus, Thomas C. G. Bosch
    TLDR Hydra can help understand human hair follicle microbiomes and develop new skin disease therapies.
    This study explores the potential of using the freshwater polyp Hydra as a model to understand the regulation of the microbiome in human hair follicles (HFs). The authors argue that despite interspecies differences, Hydra can help uncover fundamental principles of host-microbiome interactions, such as nutrient dependency, microbial interactions, and host immunity. These insights could inform the development of new microbiome-targeting therapies for human skin diseases. The research emphasizes the importance of studying simple model systems to address complex biological questions relevant to human health.
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