A Folliculocentric Perspective of Dandruff Pathogenesis: Could a Troublesome Condition Be Caused by Changes to a Natural Secretory Mechanism?

    September 2021 in “ BioEssays ”
    Susan L. Limbu, Talveen S. Purba, Matthew Harries … Ralf Paus
    Studysummary This article discusses a novel hypothesis on the role of hair follicles in dandruff pathogenesis, focusing on immune response and inflammation due to scalp microbiota changes and sebum by-products, but reports no new clinical results.
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    Research cited in this study 28

    1. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    2. Immune Cell Regulation of the Hair Cycle Experimental Dermatology · 2020
    3. The Role of the Microbiome in Scalp Hair Follicle Biology and Disease Experimental Dermatology · 2019
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    8. Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2017
    9. Ex-Vivo Measurement of Scalp Follicular Infundibulum Delivery of Zinc Pyrithione and Climbazole from an Anti-Dandruff Shampoo Journal of pharmaceutical and biomedical analysis · 2017
    10. Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles Scientific reports · 2017
    11. Stress And The Hair Growth Cycle: Cortisol-Induced Hair Growth Disruption PubMed · 2016
    12. Human Hair and the Impact of Cosmetic Procedures: A Review on Cleansing and Shape-Modulating Cosmetics Cosmetics · 2016
    13. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    14. Seborrheic Dermatitis and Dandruff: A Comprehensive Review Journal of Clinical and Investigative Dermatology · 2015
    15. Deciphering the Functions of the Hair Follicle Infundibulum in Skin Physiology and Disease Cell and Tissue Research · 2014
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    17. Zinc Therapy in Dermatology: A Review Dermatology Research and Practice · 2014
    18. A Practical Guide for the Study of Human and Murine Sebaceous Glands In Situ Experimental Dermatology · 2013
    19. A Comprehensive Pathophysiology of Dandruff and Seborrheic Dermatitis: Towards a More Precise Definition of Scalp Health Acta dermato-venereologica · 2013
    20. Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin Nature Immunology · 2012
    21. Stratum Corneum Dysfunction in Dandruff International Journal of Cosmetic Science · 2012
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    23. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
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    25. Hair Follicles and Their Role in Skin Health Expert Review of Dermatology · 2006
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    27. Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol The FASEB Journal · 2005
    28. Hair Cycle-Dependent Changes in Skin Immune Functions: Anagen-Associated Depression of Sensitization for Contact Hypersensitivity in Mice Journal of Investigative Dermatology · 1996

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