TLDR The method shows that zinc pyrithione and climbazole from anti-dandruff shampoo effectively reach the scalp.
The study developed a method to measure the delivery of zinc pyrithione (ZPT) and climbazole (CBZ) from an anti-dandruff shampoo into the scalp follicular infundibulum and onto the scalp surface. This method involved scalp cyanoacrylate (CA) biopsy sampling, a tailor-made cutting device, ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) analysis, scanning electron microscopy (SEM) measurement, and Raman imaging. The CA biopsy enabled sampling of ZPT and CBZ, while Raman imaging visualized their spatial distribution. The cutting device separated scalp surface samples from follicular infundibulum samples, and UHPLC–MS/MS quantified ZPT and CBZ accurately. This comprehensive approach successfully quantified and visualized the delivery of these antifungal agents within the scalp follicular infundibulum.
89 citations,
January 2013 in “Acta dermato-venereologica” The document concludes that dandruff and seborrheic dermatitis are linked to inflammation and skin changes, and treating them with specific shampoos can reduce these issues.
93 citations,
April 2012 in “International Journal of Cosmetic Science” Improving skin barrier and using antifungal treatments can help manage dandruff.
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September 2011 in “British journal of dermatology/British journal of dermatology, Supplement” Effective dandruff treatment requires delivering antifungal agents to the scalp follicular infundibulum.
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September 2011 in “British Journal of Dermatology” The human hair follicle can store topical compounds and be targeted for drug delivery with minimal side effects.
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January 2010 in “Journal of dermatological science” Hair follicles are promising targets for delivering drugs effectively.
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February 2009 in “European journal of pharmaceutics and biopharmaceutics” Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.
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August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” The new "differential stripping" method effectively measures how much substance gets into hair follicles.
January 2023 in “International journal of Ayurveda and pharma research” The herbal shampoo is effective and safe for use.
July 2022 in “International journal of Ayurvedic medicine” The new herbal shampoo effectively controls dandruff using natural ingredients.
32 citations,
November 2005 in “Journal of Investigative Dermatology Symposium Proceedings” Most women preferred the 1% pyrithione zinc shampoo for better hair smoothness and less frizz while controlling dandruff.
