TLDR The method shows that zinc pyrithione and climbazole from anti-dandruff shampoo effectively reach the scalp.
The study developed a method to measure the delivery of zinc pyrithione (ZPT) and climbazole (CBZ) from an anti-dandruff shampoo into the scalp follicular infundibulum and onto the scalp surface. This method involved scalp cyanoacrylate (CA) biopsy sampling, a tailor-made cutting device, ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) analysis, scanning electron microscopy (SEM) measurement, and Raman imaging. The CA biopsy enabled sampling of ZPT and CBZ, while Raman imaging visualized their spatial distribution. The cutting device separated scalp surface samples from follicular infundibulum samples, and UHPLC–MS/MS quantified ZPT and CBZ accurately. This comprehensive approach successfully quantified and visualized the delivery of these antifungal agents within the scalp follicular infundibulum.
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