TLDR Effective dandruff treatment requires delivering antifungal agents to the scalp follicular infundibulum.
The study explored the role of the scalp follicular infundibulum in treating dandruff/seborrhoeic dermatitis (D/SD) and found that effective treatment requires delivering antifungal agents, like zinc pyrithione (ZPT), to this specific area. Researchers developed three methods to measure ZPT delivery to the infundibulum and discovered that commercial ZPT shampoos effectively target this space, reducing Malassezia yeast populations. The particle size of ZPT was identified as a crucial factor for efficient delivery, highlighting the importance of targeting both the scalp surface and infundibulum for effective D/SD treatment.
109 citations,
November 2005 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Targeting hair follicles can improve skin treatments and reduce side effects.
162 citations,
August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” The new "differential stripping" method effectively measures how much substance gets into hair follicles.
316 citations,
June 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” Microspheres about 1.5 micrometers in size can best penetrate hair follicles, potentially reaching important stem cells.
405 citations,
January 2004 in “Journal of Investigative Dermatology” Hair follicle size and distribution vary significantly across different body sites.
12 citations,
October 1981 in “International Journal of Cosmetic Science” Effective anti-dandruff products work well against scalp microbes and stick to the skin.
2 citations,
March 2019 in “European Journal of Dermatology” Pharmacy-sold shampoos tend to have fewer allergens compared to those sold in other stores.
93 citations,
April 2012 in “International Journal of Cosmetic Science” Improving skin barrier and using antifungal treatments can help manage dandruff.
14 citations,
September 2021 in “International journal of molecular sciences” Zinc pyrithione needs targeted delivery to the scalp for effective dandruff treatment.
6 citations,
May 2022 in “Pharmaceutics” Zinc pyrithione dissolves quickly on the skin and in hair follicles, especially in smaller particles.
5 citations,
September 2012 in “Springer eBooks” Nanoparticles can be used to deliver drugs to hair follicles, potentially improving treatments for conditions like acne and alopecia, and could also be used for vaccine delivery and gene therapy.
