Targeted Delivery of Zinc Pyrithione to Skin Epithelia

September 2021 in “ International journal of molecular sciences ”

Sean E. Mangion, Amy Holmes, Michael S. Roberts

zinc pyrithione ZPT dandruff seborrheic dermatitis Malassezia yeasts stratum corneum inflammation scalp health

TLDR Zinc pyrithione needs targeted delivery to the scalp for effective dandruff treatment.

The document discusses the targeted delivery of zinc pyrithione (ZPT) to skin epithelia for treating dandruff and seborrheic dermatitis. It highlights ZPT's antimicrobial properties against Malassezia yeasts, which are implicated in these scalp conditions. Various studies and clinical trials demonstrate ZPT's efficacy in reducing dandruff symptoms and improving scalp health. The paper also explores ZPT's pharmacokinetics and mechanisms of action, emphasizing its role in maintaining the stratum corneum's barrier function and reducing inflammation. The conclusion is that ZPT is a potent and effective treatment for dandruff and related scalp disorders.

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