The Effects of Minoxidil, 1% Pyrithione Zinc, and a Combination of Both on Hair Density: A Randomized Controlled Trial

    August 2003 in “ British Journal of Dermatology ”
    R. S. Berger, J. L. Fu, Kenneth A. Smiles, C. B. Turner, B. M. Schnell, K. M. Werchowski, Karen M. Lammers
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    TLDR Minoxidil and pyrithione zinc combo most effectively increases hair density.
    A 6-month randomized controlled trial was conducted on 200 healthy men with Hamilton-Norwood type III vertex or type IV baldness to assess the hair growth benefits of a 1% pyrithione zinc shampoo compared to a 5% minoxidil topical solution, a placebo shampoo, and a combination of the two. Hair count results showed a significant increase in total visible hair counts for the 1% pyrithione zinc shampoo, the 5% minoxidil topical solution, and the combination treatment groups relative to the placebo shampoo after 9 weeks of treatment. The study concluded that daily use of a 1% pyrithione zinc shampoo over a 26-week treatment period can result in a modest and sustained improvement in hair growth. The combination of minoxidil and pyrithione zinc was found to be more effective in increasing hair density than either treatment alone.
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