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research Ex-vivo measurement of scalp follicular infundibulum delivery of zinc pyrithione and climbazole from an anti-dandruff shampoo

12 citations , May 2017 in “Journal of pharmaceutical and biomedical analysis”

In this study, researchers developed a method using scalp cyanoacrylate biopsy and advanced imaging techniques to effectively measure and visualize the distribution of anti-dandruff shampoo ingredients zinc pyrithione and climbazole within the scalp follicular infundibulum.

research Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations

43 citations , October 2002 in “International Journal of Cosmetic Science”

This study found that 1% ketoconazole and 1% piroctone olamine shampoos increased hair shaft thickness and reduced hair shedding in men with telogen effluvium and androgenic alopecia associated with dandruff.

research New insights on dandruff/seborrhoeic dermatitis: the role of the scalp follicular infundibulum in effective treatment strategies

46 citations , September 2011 in “British journal of dermatology/British journal of dermatology, Supplement”

This study found that certain zinc pyrithione shampoos effectively deliver antifungal agents to the scalp's follicular infundibulum, correlating with reduced Malassezia populations, likely influenced by particle size optimizing such delivery.

research A Comprehensive Pathophysiology of Dandruff and Seborrheic Dermatitis – Towards a More Precise Definition of Scalp Health

89 citations , January 2013 in “Acta dermato-venereologica”

This review examines dandruff and seborrheic dermatitis, highlighting the role of Malassezia yeasts in inflammation and hyper-proliferation, and reports no new clinical findings.

research The role of oxidative damage in poor scalp health: ramifications to causality and associated hair growth

24 citations , November 2015 in “International Journal of Cosmetic Science”

This study demonstrated that oxidative stress contributes to dandruff, and using a potentiated ZPT shampoo improves scalp and hair condition by reducing oxidative stress.

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Community Join

5 / 5 results

community What’s the most effective way to beat Serb Derm?

in Treatment 7 upvotes 2 years ago

OP struggles with scalp flakes causing hair loss and has tried Selsun Blue, Ketoconazole, and ZPT Shampoo without success. Suggestions include using salicylic acid shampoo, shaving the head, using Nizoral, and combining treatments like Minoxidil and finasteride.

community What routines helped you reduce dry scalp, flaking, and irritation?

3 upvotes 3 months ago

The conversation is about managing dry scalp, flaking, and irritation while using RU58841, minoxidil, and ketoconazole shampoo for hair loss. Suggestions include reducing minoxidil usage, using ZPT shampoo, and considering vitamin D and iron supplements.

community 34 M, should I stop minoxidil when scalp is inflammed ?

4 upvotes 1 week ago

A 34-year-old male using minoxidil experienced scalp inflammation and dandruff without new hair growth. He was advised to use minoxidil every other day, take antifungal tablets, and use dandruff shampoo, while considering finasteride as a future option.

community is this good ? did anyone try it ?

in Ketoconazole 4 upvotes 1 year ago

Ketoconazole is discussed as a treatment for hair loss, with mixed reviews on its effectiveness and side effects. Some users find it helpful for scalp conditions, while others report it makes hair feel dry and doesn't aid regrowth.

community Has anyone else had much worse hair from excessive use of Nizoral?

in Ketoconazole 19 upvotes 1 year ago

Excessive use of Nizoral can lead to dry, brittle hair and is not recommended more than 1-2 times a week. Users suggest using conditioner to mitigate dryness and note that Nizoral is more effective for treating fungal issues rather than regrowing hair.

Learn

5 / 800 results

learn Pyrithione Zinc

Can pyrithione zinc be combined with other active ingredients like ketoconazole or minoxidil? In one 26-week trial, adding zinc pyrithione shampoo to minoxidil gave no extra hair growth (Berger et al., Br J Dermatol 2003). Ask a pharmacist before combining medicated shampoos with a hair-loss medicine.
How does pyrithione zinc help reduce dandruff and irritation related to hair loss? In small controlled studies, zinc pyrithione shampoo reduced dandruff; lab studies suggest it works by slowing the growth of Malassezia yeast. It has not been shown to treat hair loss.
Is it okay to use pyrithione zinc daily, or should it be alternated with a gentle cleanser? US labels for zinc pyrithione dandruff shampoos say to use them at least twice a week, and studies have tested daily use for up to 26 weeks. In the EU, zinc pyrithione has been banned in cosmetics since 2022 because it is classified as toxic for reproduction, so ask a pharmacist if you are pregnant or trying to conceive.

learn zinc PCA

Can zinc help with scalp issues like irritation, dandruff, or inflammation? Zinc pyrithione shampoo is an established over-the-counter dandruff treatment. Evidence for other forms of zinc, including zinc PCA, or for general scalp irritation is weak.
Should zinc be taken orally or applied topically for better results in hair growth? Oral zinc has been studied mainly in people with a low blood zinc level, and no trial compares oral and topical zinc for hair growth. Zinc pyrithione shampoo gave a small hair-count gain in one trial, less than half that of minoxidil.

learn Ketoconazole

Antifungal, best known as a dandruff shampoo

learn Caffeine

Stimulant used in hair shampoos and lotions

learn Hairfect Rx™ (Strut complex)

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