Hair Follicle Targeting with Nanoparticles

In 2012, researchers investigated the use of nanoparticles for targeted drug delivery to hair follicles. They found that hair follicles are significant entry points for topically applied substances, and that the physicochemical properties of nanoparticles, such as size and surface properties, significantly influence their ability to penetrate hair follicles. Smaller nanoparticles (10-500 nm) were found to penetrate deeper into the hair follicle canal than larger ones. The study suggested that this method could be used to deliver drugs to specific regions of the hair follicle, potentially improving treatments for conditions like acne and alopecia. The research also suggested potential uses for vaccine delivery and gene therapy for hair-related conditions. However, more studies were needed to understand the potential risks and benefits of this approach.