Advances in Hair Diseases

November 2008 in “ Advances in Dermatology ”

Maria Hordinsky

TLDR The review highlights the importance of stem cells in hair health and suggests new treatment strategies for hair loss conditions.

In the 2008 review, Maria Hordinsky explored the complexities of hair follicle biology, including the role of stem cells in the bulge region and the molecules involved in follicle differentiation and cycling. The review identified genes responsible for structural hair abnormalities and hair color, and discussed the hair cycle phases. It emphasized the importance of the follicular bulge for stem cells and immune privilege, noting the implications for conditions like alopecia areata and cicatricial alopecias. The latter were classified by inflammatory cell type, with treatment strategies proposed. The review also addressed hair cycle abnormalities, the protective role of CD200 in autoimmune hair loss, triggers and associations of telogen effluvium, genetic and hormonal factors in androgenetic alopecia, and the lack of FDA-approved treatments for alopecia areata. Additionally, it touched on the potential of hair follicle stem cells in regenerative medicine and the role of Malassezia in dandruff, while suggesting future research directions in hair biology and tissue engineering.

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Research cited in this study

21 / 21 results

research The Genetics of Hair Shaft Disorders

59 citations , June 2008 in “Journal of The American Academy of Dermatology”

The article explains the genetic causes and symptoms of various hair disorders and highlights the need for more research to find treatments.

research Interventions for Alopecia Areata

164 citations , April 2008 in “Cochrane library”

Current treatments for alopecia show no significant long-term benefits.

research Hair Follicle-Specific Keratins And Their Diseases

138 citations , March 2007 in “Experimental cell research”

Only a few hair-specific keratins are linked to inherited hair disorders.

research Genomewide Scan for Linkage Reveals Evidence of Several Susceptibility Loci for Alopecia Areata

143 citations , January 2007 in “The American Journal of Human Genetics”

Certain genes on chromosomes 6, 10, 16, and 18 may increase the risk of alopecia areata.

research The Diagnosis and Treatment of Iron Deficiency and Its Potential Relationship to Hair Loss

207 citations , April 2006 in “Journal of The American Academy of Dermatology”

Iron deficiency may be related to hair loss, but there's not enough evidence to recommend iron screening or supplements for all hair loss patients.

research Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves

319 citations , November 2005 in “Proceedings of the National Academy of Sciences”

Hair follicle stem cells can help repair damaged nerves.

research Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells

205 citations , April 2005 in “Journal of Investigative Dermatology”

Scientists have found a way to create hair follicles from skin cells of newborn mice, which can grow and cycle naturally when injected into adult mouse skin.

research Evaluation and Treatment of Male and Female Pattern Hair Loss

203 citations , December 2004 in “Journal of The American Academy of Dermatology”

Early diagnosis and treatment, using finasteride, minoxidil, or hair transplantation, improves hair loss outcomes.

Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

208 citations , December 2003 in “Journal of Investigative Dermatology”

Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.

research Is the Loose Anagen Hair Syndrome a Keratin Disorder?

84 citations , April 2002 in “Archives of Dermatology”

Loose anagen hair syndrome may be caused by keratin gene mutations.

research Kenogen

90 citations , January 2002 in “Dermatology”

Kenogen is a resting phase in hair follicles that may contribute to baldness, especially in androgenetic alopecia.

research Atrichia Caused by Mutations in the Vitamin D Receptor Gene Is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene

139 citations , September 2001 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mutations in the Vitamin D receptor gene can cause hair loss similar to mutations in the Hairless gene.

research Towards a Molecular Understanding of Hair Loss and Its Treatment

236 citations , July 2001 in “Trends in Molecular Medicine”

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.

research Lack of Efficacy of Finasteride in Postmenopausal Women with Androgenetic Alopecia

239 citations , November 2000 in “Journal of The American Academy of Dermatology”

Finasteride doesn't effectively treat hair loss in postmenopausal women.

research Alopecia Areata Update

49 citations , April 2000 in “Journal of The American Academy of Dermatology”

Despite progress in treatment, the exact cause of Alopecia areata is still unknown.

research The Midline Part: An Important Physical Clue to the Clinical Diagnosis of Androgenetic Alopecia in Women

90 citations , January 1999 in “Journal of The American Academy of Dermatology”

"Christmas tree" pattern helps diagnose female hair loss.

research Finasteride in the Treatment of Men with Androgenetic Alopecia

581 citations , October 1998 in “Journal of The American Academy of Dermatology”

Finasteride safely and effectively treats male pattern hair loss, but may cause reversible sexual issues and harm male fetuses.

research Alopecia Universalis Associated with a Mutation in the Human hairless Gene

412 citations , January 1998 in “Science”

A mutation in the human hairless gene causes alopecia universalis.

research Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix

175 citations , August 1997 in “Nature Genetics”

research Telogen Effluvium: New Concepts and Review

69 citations , March 1993 in “Archives of Dermatology”

The document says there are five types of hair loss conditions and different causes, including drugs.

research Structural Abnormalities of the Hair Shaft

126 citations , January 1987 in “Journal of The American Academy of Dermatology”

The document concludes that understanding hair structure is key to diagnosing hair abnormalities and recommends gentle hair care for management.

Related Community Posts Join

6 / 1000+ results

community HairClone developing cell replacement treatments for Hair Loss

6 upvotes 6 years ago

HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community UVA researchers discovered stem cells that plays a crucial role in hair growth - We are closer than ever to the cure!

in Research/Science 282 upvotes 8 months ago

Researchers at the University of Virginia discovered a new group of stem cells in hair follicles that could potentially restore hair growth. The findings suggest that activating these stem cells might offer a new way to combat hair loss, though practical treatments are still years away.

community Finally, some real breakthroughs. A comparison of the two leading baldness treatments: PP405 versus ABS-201

in Technology 103 upvotes 1 week ago

PP405 and ABS-201 are promising treatments for male pattern baldness. PP405 shows rapid hair growth in human trials, while ABS-201 shows significant regrowth in animal studies but is still in early human trials.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.

in Research/Science 41 upvotes 9 months ago

ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.

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6 / 1000+ results

research The Hair Follicle as a Dynamic Mini-Organ

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Neuroendocrinology of Epithelial Hair Follicle Stem Cells

research Development and Homeostasis of the Sebaceous Gland

107 citations , August 2012 in “Seminars in Cell & Developmental Biology”

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

Advances in Hair Diseases

Research cited in this study

research The Genetics of Hair Shaft Disorders

research Interventions for Alopecia Areata

research Hair Follicle-Specific Keratins And Their Diseases

research Genomewide Scan for Linkage Reveals Evidence of Several Susceptibility Loci for Alopecia Areata

research The Diagnosis and Treatment of Iron Deficiency and Its Potential Relationship to Hair Loss

research Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves

research Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells

research Evaluation and Treatment of Male and Female Pattern Hair Loss

research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

research Is the Loose Anagen Hair Syndrome a Keratin Disorder?

research Kenogen

research Atrichia Caused by Mutations in the Vitamin D Receptor Gene Is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene

research Towards a Molecular Understanding of Hair Loss and Its Treatment

research Lack of Efficacy of Finasteride in Postmenopausal Women with Androgenetic Alopecia

research Alopecia Areata Update

research The Midline Part: An Important Physical Clue to the Clinical Diagnosis of Androgenetic Alopecia in Women

research Finasteride in the Treatment of Men with Androgenetic Alopecia

research Alopecia Universalis Associated with a Mutation in the Human hairless Gene

research Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix

research Telogen Effluvium: New Concepts and Review

research Structural Abnormalities of the Hair Shaft

Related Community Posts Join

community HairClone developing cell replacement treatments for Hair Loss

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

community UVA researchers discovered stem cells that plays a crucial role in hair growth - We are closer than ever to the cure!

community Finally, some real breakthroughs. A comparison of the two leading baldness treatments: PP405 versus ABS-201

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.

Similar Research

research The Hair Follicle as a Dynamic Mini-Organ

research Neuroendocrinology of Epithelial Hair Follicle Stem Cells

research Towards a Molecular Understanding of Hair Loss and Its Treatment

research Dynamic Signals for Hair Follicle Development and Regeneration

research The G-Protein Coupled Receptor Kinase 2 (GRK2) Orchestrates Hair Follicle Homeostasis

research Development and Homeostasis of the Sebaceous Gland