The G-Protein Coupled Receptor Kinase 2 (GRK2) Orchestrates Hair Follicle Homeostasis
April 2024
in “
bioRxiv (Cold Spring Harbor Laboratory)
”
G protein-coupled receptor kinase 2 GRK2 hair follicle homeostasis keratinocyte-specific knockout hair germ region anagen phase cyst-like structures catagen phase dermal papilla hair follicle stem cell bulge destruction hair loss alopecia areata immune-mediated alopecias hair follicle hair growth phase immune-related hair loss
Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.
Studysummary In a keratinocyte-specific knockout mouse model, this study found that deleting GRK2 disrupted hair follicle homeostasis, causing cyst-like structures, abnormal growth patterns, and eventual hair loss, suggesting potential links to immune-mediated alopecias.
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