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    Optimization of Hair Follicle Spheroids for Hair-On-A-Chip

    January 2024 in “ Biomaterials Science ”
    Subin Jeong, Hyeon‐Min Nam, Gun Yong Sung
    Studysummary This study explored hair follicle research by co-culturing dermal papilla cells, keratinocytes, and endothelial cells in spheroids, finding elevated hair growth factor expression and potential for creating skin equivalents with hair through a "hair-on-a-chip" approach.
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    Research cited in this study 24

    1. Recent Advances in Understanding the Role of the Skin Microbiome in the Treatment of Atopic Dermatitis Experimental Dermatology · 2023
    2. In Vitro Hair Follicle Growth Model for Drug Testing Scientific Reports · 2023
    3. Microenvironmental Reprogramming of Human Dermal Papilla Cells for Hair Follicle Tissue Engineering Acta Biomaterialia · 2022
    4. Skin-On-A-Chip Strategies For Human Hair Follicle Regeneration Experimental Dermatology · 2022
    5. Hair Growth Promotion by Delta-Opioid Receptor Activation Biomolecules & Therapeutics · 2021
    6. Recreation of a Hair Follicle Regenerative Microenvironment: Successes and Pitfalls Bioengineering & translational medicine · 2021
    7. Hair Follicle Germs Containing Vascular Endothelial Cells for Hair Regenerative Medicine Scientific Reports · 2021
    8. The Microfollicle: A Model of the Human Hair Follicle for In Vitro Studies In Vitro Cellular & Developmental Biology - Animal · 2020
    9. Microtechnology-Based Methods for Organoid Models Microsystems & Nanoengineering · 2020
    10. Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss International Journal of Molecular Sciences · 2020
    11. Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods Skin Pharmacology and Physiology · 2020
    12. Self-Organizing Hair Peg-Like Structures From Dissociated Skin Progenitor Cells: New Insights for Human Hair Follicle Organoid Engineering and Turing Patterning in an Asymmetric Morphogenetic Field Experimental Dermatology · 2019
    13. Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach Nature Communications · 2018
    14. miR-195-5p Regulates Hair Follicle Inductivity of Dermal Papilla Cells by Suppressing Wnt/β-Catenin Activation BioMed Research International · 2018
    15. Epidermal Growth Factor Promotes Proliferation of Dermal Papilla Cells via Notch Signaling Pathway Biochimie · 2016
    16. Treatment of MSCs with Wnt1a-Conditioned Medium Activates DP Cells and Promotes Hair Follicle Regrowth Scientific Reports · 2014
    17. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    18. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    19. Adenovirus-Mediated Wnt10b Overexpression Induces Hair Follicle Regeneration Journal of Investigative Dermatology · 2012
    20. Videodermoscopy in the Evaluation of Hair and Scalp Disorders Journal of The American Academy of Dermatology · 2006
    21. K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), And K28 (K25irs4) Represent The Type I Inner Root Sheath Keratins Of The Human Hair Follicle Journal of Investigative Dermatology · 2006
    22. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    23. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    24. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999

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    1. Preparing the Hair Follicle Canal for Hair Shaft Emergence Experimental dermatology · 2020