Nanoparticle-Based Targeting of Vaccine Compounds to Skin Antigen-Presenting Cells by Hair Follicles and Their Transport in Mice
December 2008
in “
The journal of investigative dermatology/Journal of investigative dermatology
”
hair follicles antigen-presenting cells polystyrene nanoparticles modified vaccinia Ankara green-fluorescent protein fibered-based confocal microscopy perifollicular transcutaneously ovalbumin coding DNA humoral immune response cellular immune response draining lymph nodes vaccinia virus APCs MVA TC
Studysummary In this study, transcutaneously applied nanoparticles and viral vectors were shown to penetrate murine hair follicles, internalize in antigen-presenting cells, and induce immune responses, suggesting a promising approach for vaccine delivery.
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