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In this case study, a 55-year-old male with a history of hypospadias repair developed urinary complications due to urethral hair bezoars, and the researchers reported that transcutaneous ND:YAG laser epilation effectively removed urethral hair, preventing recurrence of such issues.

This study found that 40 nm nanoparticles can effectively penetrate into hair follicles and epidermal Langerhans cells in human skin samples, potentially enabling efficient transcutaneous vaccine delivery.

This study found that in vivo, a novel microneedle system for valproic acid delivery may improve hair regrowth efficacy by upregulating hair follicle development pathways more effectively than topical application.

This study reviewed eight studies investigating transcutaneous drug delivery via fractional laser and microneedling for alopecia treatment, with six studies showing improved hair regrowth over topical therapy alone, suggesting its potential as a promising treatment strategy, although further research is needed to refine treatment parameters.

This article reviews 12 clinical applications for transcutaneous laser-assisted drug delivery in skin disorders and concludes that it has potential for broader treatment use.