The Rise of Transcutaneous Drug Delivery for the Management of Alopecia: A Review of Existing Literature and an Eye Towards the Future

    October 2018 in “ Journal of Cosmetic and Laser Therapy ”
    Angela Wipf, Nicholas C. Boysen, Maria Hordinsky … Ronda S. Farah
    Studysummary This study reviewed eight studies investigating transcutaneous drug delivery via fractional laser and microneedling for alopecia treatment, with six studies showing improved hair regrowth over topical therapy alone, suggesting its potential as a promising treatment strategy, although further research is needed to refine treatment parameters.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 29

    1. Oral Tofacitinib Monotherapy in Korean Patients with Refractory Moderate-to-Severe Alopecia Areata: A Case Series Journal of the American Academy of Dermatology · 2017
    2. Randomized Trial of Electrodynamic Microneedle Combined with 5% Minoxidil Topical Solution for the Treatment of Chinese Male Androgenetic Alopecia Journal of Cosmetic and Laser Therapy · 2017
    3. Platelet-Rich Plasma with Microneedling in Androgenetic Alopecia Along with Dermoscopic Pre- and Post-Treatment Evaluation Journal of Cosmetic Dermatology · 2017
    4. Three-Microneedle Device as an Effective Option for Intralesional Corticosteroid Administration for the Treatment of Alopecia Areata The Journal of Dermatology · 2017
    5. Enhancing Hair Growth in Male Androgenetic Alopecia by a Combination of Fractional CO2 Laser Therapy and Hair Growth Factors Lasers in Medical Science · 2017
    6. A Comparative Study of Microneedling with Platelet-Rich Plasma Plus Topical Minoxidil (5%) and Topical Minoxidil (5%) Alone in Androgenetic Alopecia International Journal of Trichology · 2017
    7. Using Automated Microneedling with Platelet-Rich Plasma for Treating Cicatricial Alopecia, Recalcitrant Alopecia Areata, and Traction Alopecia: Case Report Journal of The American Academy of Dermatology · 2016
    8. Platelet-Rich Plasma Microneedling Versus 5% Topical Minoxidil in the Treatment of Patterned Hair Loss Journal of the Egyptian Women's Dermatologic Society (Print) · 2016
    9. Current Treatments for Alopecia Areata ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2015
    10. Response to Microneedling Treatment in Men with Androgenetic Alopecia Who Failed to Respond to Conventional Therapy Indian Journal of Dermatology · 2015
    11. Transepidermal Drug Delivery: A New Treatment Option for Areata Alopecia? Journal of cosmetic and laser therapy · 2014
    12. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    13. Alopecia Areata: Successful Outcome with Microneedling and Triamcinolone Acetonide Journal of Cutaneous and Aesthetic Surgery · 2014
    14. Clinical Effects of Non-Ablative and Ablative Fractional Lasers on Various Hair Disorders: A Case Series of 17 Patients Journal of Cosmetic and Laser Therapy · 2013
    15. A Randomized Evaluator Blinded Study of Effect of Microneedling in Androgenetic Alopecia: A Pilot Study International Journal of Trichology · 2013
    16. Effects of Topical Application of Growth Factors Followed by Microneedle Therapy in Women with Female Pattern Hair Loss: A Pilot Study Journal of Dermatology · 2012
    17. Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia British Journal of Dermatology · 2012
    18. The Effect of a 1550 Nm Fractional Erbium-Glass Laser in Female Pattern Hair Loss Journal of The European Academy of Dermatology and Venereology · 2011
    19. Fractional Photothermolysis Laser Treatment of Male Pattern Hair Loss Dermatologic Surgery · 2010
    20. Quality of Life in Alopecia Areata: A Study of 60 Cases Journal of Investigative Dermatology · 2010
    21. Photodynamic Therapy with Methyl 5-Aminolevulinate Acid Might Be Ineffective in Recalcitrant Alopecia Totalis Regardless of Using a Microneedle Roller to Increase Skin Penetration Dermatologic surgery · 2010
    22. Male Androgenetic Alopecia: Population-Based Study in 1,005 Subjects International Journal of Trichology · 2009
    23. Evaluation and Treatment of Male and Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2004
    24. Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors British Journal of Dermatology · 2003
    25. Hair Density, Hair Diameter, and the Prevalence of Female Pattern Hair Loss British Journal of Dermatology · 2001
    26. The Psychosocial Consequences of Androgenetic Alopecia: A Review of the Research Literature British Journal of Dermatology · 1999
    27. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998
    28. Topical Minoxidil in Male Pattern Baldness: Effects of Discontinuation of Treatment Journal of The American Academy of Dermatology · 1987
    29. Use of Topical Minoxidil in the Treatment of Male Pattern Baldness Journal of The American Academy of Dermatology · 1987

    Related research 6

    1. Allergic Contact Dermatitis Due to Minoxidil in a Patient With Alopecia Areata Actas Dermo-Sifiliográficas · 2022
    2. Topical Minoxidil for the Treatment of Alopecia Areata PubMed · 2017
    3. Effectivity of Minoxidil as a Treatment for Alopecia Areata DOAJ (DOAJ: Directory of Open Access Journals) · 2013
    4. Treatments for Androgenetic Alopecia and Alopecia Areata Drugs · 2001
    5. Alopecia Areata Treated With Topical Minoxidil Archives of Dermatology · 1984
    6. Topical Minoxidil in the Treatment of Alopecia Areata BMJ · 1983