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Glossary Antigen-Presenting Cells

help activate T-cells by displaying foreign antigens

Antigen-Presenting Cells (APCs) are a type of immune cell that helps the body recognize and fight off pathogens. They capture antigens (foreign substances) and present them on their surface to T-cells, which then initiate an immune response. Examples of APCs include dendritic cells, macrophages, and B cells.

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research Nanoparticle-Based Targeting of Vaccine Compounds to Skin Antigen-Presenting Cells By Hair Follicles and their Transport in Mice

119 citations , December 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, transcutaneously applied nanoparticles and viral vectors were shown to penetrate murine hair follicles, internalize in antigen-presenting cells, and induce immune responses, suggesting a promising approach for vaccine delivery.

research A Chronic Contact Eczema Impedes Migration of Antigen-Presenting Cells in Alopecia Areata

24 citations , May 2006 in “Journal of Investigative Dermatology”

This study found that allergen treatment in alopecia areata mice appeared to alter leukocyte subset distribution and impaired dendritic cell migration, which may affect T-cell activation and hair follicle recovery.

research Antigen presenting cells in the skin of a patient with hair loss and systemic lupus erythematosus.

9 citations , September 2009 in “PubMed”

This case report presents the first evidence of significant antigen presenting cells around hair follicles in a patient with alopecia due to active systemic lupus erythematosus.

research Targeting of Skin Antigen-Presenting Cells

January 2010 in “Journal of Animal Science”

This study demonstrated that transcutaneous vaccination via cyanoacrylate skin surface stripping effectively induced both CD4 and CD8 T cell responses in humans, offering a promising alternative to intramuscular injection.

research Particle-based transcutaneous administration of HIV-1 p24 protein to human skin explants and targeting of epidermal antigen presenting cells

30 citations , January 2014 in “Journal of Controlled Release”

This study concluded that combining cyanoacrylate skin surface stripping with particle-based antigen delivery effectively targets HIV-1 p24 protein to skin cells, supporting its potential for needle-free transcutaneous vaccination.

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community Taking Charge of Your Hair: The "Big 3 Stack" Explained for 2023

129 upvotes 3 years ago

The "Big 3 Stack" for hair loss treatment, which includes Minoxidil for hair density improvement, Ketoconazole shampoo for enhancing hair volume and thickness, and Finasteride for blocking hair loss causing hormones. Microneedling can boost Minoxidil's effects.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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