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GlossaryHLA Class I

proteins on cell surfaces presenting peptides to immune T cells

HLA Class I, also known as Human Leukocyte Antigen Class I, refers to a group of proteins found on the surface of almost all cells in the body. These proteins play a crucial role in the immune system by presenting fragments of proteins (peptides) from inside the cell to T cells, which helps the immune system recognize and respond to infected or abnormal cells, such as those infected by viruses or transformed into cancer cells.

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Study of Human Leukocyte Antigen in 13 Cases of Familial Frontal Fibrosing Alopecia: CYP21A2 Gene p.V281L Mutation from Congenital Adrenal Hyperplasia Linked to HLA Class I Haplotype HLA-A*33:01; B*14:02; C*08:02 as a Genetic Marker

research Study of Human Leukocyte Antigen in 13 Cases of Familial Frontal Fibrosing Alopecia: CYP21A2 Gene p.V281L Mutation from Congenital Adrenal Hyperplasia Linked to HLA Class I Haplotype HLA-A33:01; B14:02; C*08:02 as a Genetic Marker

7 citations, January 2019 in “Australasian Journal of Dermatology”

A genetic marker linked to a type of hair loss was found in most patients studied.

research Human Leukocyte Antigen Class II Alleles Are Associated with Risk of Alopecia Areata

36 citations, July 2007 in “Journal of Investigative Dermatology”

Certain HLA class II alleles increase or decrease the risk of alopecia areata.

research Cell Surface B2m-Free Human Leukocyte Antigen Monomers and Dimers: Are They Neo-HLA Class and Proto-HLA?

3 citations, July 2023 in “Biomolecules”

B2m-free HLA variants may be a new class of HLA important in immune responses and diseases.

research Linking Allergy to Mercury to HLA and Burning Mouth Syndrome

6 citations, January 2007 in “Journal of the European Academy of Dermatology and Venereology”

Mercury allergy linked to specific genes may contribute to burning mouth syndrome, and silicon might play a role in maintaining healthy hair.

research Organ Specificity in Autoimmune Diseases: Thyroid and Islet Autoimmunity in Alopecia Areata

32 citations, March 2015 in “The Journal of Clinical Endocrinology & Metabolism”

Alopecia areata is linked to thyroid autoimmunity but not type 1 diabetes.

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