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    Glossary HLA Class I

    proteins on cell surfaces presenting peptides to immune T cells

    HLA Class I, also known as Human Leukocyte Antigen Class I, refers to a group of proteins found on the surface of almost all cells in the body. These proteins play a crucial role in the immune system by presenting fragments of proteins (peptides) from inside the cell to T cells, which helps the immune system recognize and respond to infected or abnormal cells, such as those infected by viruses or transformed into cancer cells.

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    1. Study of Human Leukocyte Antigen ( HLA ) in 13 cases of familial frontal fibrosing alopecia: CYP 21A2 gene p.V281L mutation from congenital adrenal hyperplasia linked to HLA class I haplotype HLA ‐ A*33:01 ; B*14:02; C*08:02 as a genetic marker Australasian Journal of Dermatology · 2019 · 7 citations
    2. Human Leukocyte Antigen Class II Alleles Are Associated with Risk of Alopecia Areata Journal of Investigative Dermatology · 2007 · 36 citations
    3. Major Histocompatibility Complex Class I Chain-Related Gene A Polymorphisms and Extended Haplotypes Are Associated with Familial Alopecia Areata Journal of Investigative Dermatology · 2005 · 44 citations
    4. Cell Surface B2m-Free Human Leukocyte Antigen (HLA) Monomers and Dimers: Are They Neo-HLA Class and Proto-HLA? Biomolecules · 2023 · 3 citations
    5. Dandruff lesional scalp skin exhibits epidermal T cell infiltration and a weakened hair follicle immune privilege International Journal of Cosmetic Science · 2024
    6. Exacerbation of alopecia areata during pegylated interferon alpha-2b and ribavirin therapy, possibly due to the collapse of hair follicle immune privilege European Journal of Dermatology · 2014 · 10 citations
    7. Organ Specificity in Autoimmune Diseases: Thyroid and Islet Autoimmunity in Alopecia Areata The Journal of Clinical Endocrinology & Metabolism · 2015 · 32 citations
    8. Somatostatin Expression in Human Hair Follicles and Its Potential Role in Immune Privilege 2013 · 27 citations
    9. The role of somatostatin expression in hair follicle immune privilege 2012
    10. Alopecia areata update Journal of The American Academy of Dermatology · 2010 · 391 citations
    11. Alopecia Areata American Journal of Clinical Dermatology · 2000 · 50 citations
    12. Alopecia areata update Journal of The American Academy of Dermatology · 2000 · 49 citations
    13. Alopecia Areata KARGER eBooks · 2008 · 24 citations
    14. The aetiology and pathogenesis of alopecia areata Journal of Dermatological Science · 1994 · 17 citations
    15. Alopecia Areata: A Comprehensive Review of Pathogenesis, Diagnosis, and Emerging Therapeutics Journal of Advances in Biology & Biotechnology · 2026
    16. Genetics of Alopecia Encyclopedia of Life Sciences · 2012
    17. Pathophysiology of Alopecia Areata in the Pediatric Patient Pediatric Dermatology · 2025 · 5 citations
    18. A comparative analysis of immune privilege in pregnancy and cancer in the context of checkpoint blockade immunotherapy Seminars in Oncology · 2018 · 16 citations
    19. 307 Computer-assisted epitope prediction revealed potential autoantigens associated with human alopecia areata Journal of Investigative Dermatology · 2018
    20. Cutaneous Lupus Erythematosus Springer eBooks · 2017
    21. Linking allergy to mercury to HLA and burning mouth syndrome Journal of the European Academy of Dermatology and Venereology · 2007 · 6 citations
    22. Adrenal 21-hydroxylase gene mutations in Slovenian hyperandrogenic women: evaluation of corticotrophin stimulation and HLA polymorphisms in screening for carrier status European journal of endocrinology · 1999 · 19 citations
    23. Human gene correlation analysis (HGCA): A tool for the identification of transcriptionally co-expressed genes BMC Research Notes · 2012 · 24 citations
    24. Urinary 5-ene-steroid excretion in non-classical congenital adrenal hyperplasia due to 3β-hydroxysteroid dehydrogenase deficiency (NC-3BHSD) Journal of Steroid Biochemistry · 1990 · 3 citations
    25. Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 MKG2D Lymphocytes of Alopecia Areata Patients 2018 · 15 citations
    26. Association of psoriasis and psoriatic arthritis with human leukocyte antigen and killer cell immunoglobulin–like receptor gene frequency: A multiethnic population study Journal of The American Academy of Dermatology · 2009
    27. Alopecia areata after HLA-identical BMT from an affected, sibling donor Bone marrow transplantation · 2014 · 4 citations
    28. Healthy individuals genetically at-risk for the development of Pemphigus vulgaris or Alopecia areata share disease-like cytokine dysregulation Frontiers in Immunology · 2025 · 1 citations
    29. Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02 Nature Communications · 2019 · 115 citations
    30. MHC Class I-Like MILL Molecules Are β2-Microglobulin-Associated, GPI-Anchored Glycoproteins That Do Not Require TAP for Cell Surface Expression The Journal of Immunology · 2006 · 16 citations