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GlossaryHLA Class I

proteins on cell surfaces presenting peptides to immune T cells

HLA Class I, also known as Human Leukocyte Antigen Class I, refers to a group of proteins found on the surface of almost all cells in the body. These proteins play a crucial role in the immune system by presenting fragments of proteins (peptides) from inside the cell to T cells, which helps the immune system recognize and respond to infected or abnormal cells, such as those infected by viruses or transformed into cancer cells.

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Study of Human Leukocyte Antigen in 13 Cases of Familial Frontal Fibrosing Alopecia: CYP21A2 Gene p.V281L Mutation from Congenital Adrenal Hyperplasia Linked to HLA Class I Haplotype HLA-A*33:01; B*14:02; C*08:02 as a Genetic Marker

research Study of Human Leukocyte Antigen in 13 Cases of Familial Frontal Fibrosing Alopecia: CYP21A2 Gene p.V281L Mutation from Congenital Adrenal Hyperplasia Linked to HLA Class I Haplotype HLA-A33:01; B14:02; C*08:02 as a Genetic Marker

7 citations, January 2019 in “Australasian Journal of Dermatology”

A genetic marker linked to a type of hair loss was found in most patients studied.

research Alopecia Areata Update

49 citations, April 2000 in “Journal of The American Academy of Dermatology”

Despite progress in treatment, the exact cause of Alopecia areata is still unknown.

research Alopecia Areata: Pathogenesis, Genetic Factors, and Treatments Using Mouse Models

24 citations, January 2008 in “KARGER eBooks”

The document concludes that ongoing research using animal models is crucial for better understanding and treating Alopecia Areata.

research Alopecia Areata: Clinical Review and Treatment Approaches

50 citations, March 2000 in “American Journal of Clinical Dermatology”

Alopecia Areata has no guaranteed treatment for hair regrowth, but options like corticosteroids and minoxidil are used, with future research focusing on genetic and immune therapies.

research The Etiology and Pathogenesis of Alopecia Areata

17 citations, July 1994 in “Journal of Dermatological Science”

The cause of alopecia areata is likely a mix of genetics, immune system issues, and environmental factors, with more research needed to understand it fully.

research Human Leukocyte Antigen Class II Alleles Are Associated with Risk of Alopecia Areata

36 citations, July 2007 in “Journal of Investigative Dermatology”

Certain HLA class II alleles increase or decrease the risk of alopecia areata.

research Alopecia Areata Update

391 citations, January 2010 in “Journal of The American Academy of Dermatology”

Half of people with Alopecia Areata may see hair regrowth within a year without treatment, but recovery is unpredictable.

research Genetics of Alopecia

April 2012 in “Encyclopedia of Life Sciences”

Different genes are linked to various types of hair loss.

research Organ Specificity in Autoimmune Diseases: Thyroid and Islet Autoimmunity in Alopecia Areata

32 citations, March 2015 in “The Journal of Clinical Endocrinology & Metabolism”

Alopecia areata is linked to thyroid autoimmunity but not type 1 diabetes.

research Somatostatin Expression in Human Hair Follicles and Its Potential Role in Immune Privilege

27 citations, January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

Somatostatin may help protect hair follicles from immune attacks.

research Cell Surface B2m-Free Human Leukocyte Antigen Monomers and Dimers: Are They Neo-HLA Class and Proto-HLA?

3 citations, July 2023 in “Biomolecules”

B2m-free HLA variants may be a new class of HLA important in immune responses and diseases.

research Alopecia Areata: Autoimmune Nature, Genetic Associations, and Treatments

1 citations, August 2005 in “Springer eBooks”

Alopecia areata is an autoimmune disease with genetic links, treatable with certain medications, and can affect mental health.

research The Pathogenesis of Alopecia Areata

89 citations, October 1996 in “Dermatologic Clinics”

Alopecia areata is likely caused by a combination of genetic factors and immune system dysfunction, and may represent different diseases with various causes.

research Immune Privilege and Alopecia Areata

4 citations, April 2010 in “Expert review of dermatology”

Restoring immune privilege in hair follicles could help treat certain types of hair loss.

research Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 NKG2D Lymphocytes in Alopecia Areata Patients

15 citations, December 2018 in “International journal of environmental research and public health/International journal of environmental research and public health”

EGCG may help treat alopecia areata by blocking certain immune responses and reducing specific harmful immune cells.

research Genome-Wide Association Study of Alopecia Areata in Taiwan: The Conflict Between Individuals and Hair Follicles

1 citations, September 2023 in “Clinical, cosmetic and investigational dermatology”

Certain genetic variants linked to immune response increase the risk of alopecia areata in Taiwanese people.

research Alopecia Areata: Clinical Perspective and an Insight into Pathogenesis

15 citations, April 2003 in “Journal of dermatology”

Alopecia areata causes hair loss due to an immune attack on hair follicles, influenced by genetics and environment.

research Alopecia Areata After HLA-Identical Bone Marrow Transplant from an Affected Sibling Donor

4 citations, January 2014 in “Bone marrow transplantation”

Alopecia areata can be transferred through stem cell transplants from affected siblings.

research Clinical and Genetic Aspects of Alopecia Areata: A Cutting Edge Review

1 citations, June 2023 in “Genes”

Hair loss from Alopecia Areata is caused by both genes and environment, with several treatments available but challenges in cost and relapse remain.

research Alopecia Areata: Genetic and Immunological Insights

1 citations, January 2017 in “Springer eBooks”

Understanding the immune-related causes of Alopecia Areata has led to potential treatments like JAK inhibitors.

research Autoimmunity: Alopecia Areata

143 citations, January 2004 in “Journal of Investigative Dermatology Symposium Proceedings”

Alopecia areata is an autoimmune disease causing hair loss, treatable with immune-modulating drugs, and linked to genetics.

Human FOXN1 Deficiency Is Associated with Alpha Beta Double-Negative and FoxP3 Positive T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation

research Human FOXN1 Deficiency Is Associated with Alpha Beta Double-Negative and FoxP3 Positive T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation

32 citations, May 2012 in “PloS one”

Thymic transplantation normalized some T-cells but not others, maintaining immune function.

Genotyping Of The Rs1800440 Polymorphism In CYP1B1 Gene And The Rs9258883 Polymorphism In HLA-B Gene In A Spanish Cohort Of 223 Patients With Frontal Fibrosing Alopecia

research Genotyping Of The Rs1800440 Polymorphism In CYP1B1 Gene And The Rs9258883 Polymorphism In HLA-B Gene In A Spanish Cohort Of 223 Patients With Frontal Fibrosing Alopecia

1 citations, September 2023 in “Acta dermato-venereologica”

Certain genetic variants are linked to frontal fibrosing alopecia in Spanish patients.

research Epidemiology of Vitiligo, Associated Autoimmune Diseases, and Audiological Abnormalities: Ankara Study of 80 Patients in Turkey

88 citations, February 2010 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Vitiligo is linked to autoimmune diseases and hearing issues, so hearing tests are recommended for patients.

research Genetic Basis of Alopecia Areata

40 citations, October 2012 in “Dermatologic clinics”

More research is needed to understand the genetic causes of Alopecia areata to develop better treatments.

research Lymphocytes, Neuropeptides, And Genes Involved In Alopecia Areata

286 citations, August 2007 in “Journal of Clinical Investigation”

Alopecia areata is an autoimmune disease where T cells attack hair follicles.

research A Comparative Analysis of Immune Privilege in Pregnancy and Cancer in the Context of Checkpoint Blockade Immunotherapy

16 citations, March 2018 in “Seminars in Oncology”

The document concludes that pregnancy and cancer share immune evasion tactics, but more research is needed before using checkpoint blockade immunotherapy in pregnant cancer patients to avoid harm to the placenta.

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Related Terms

Research

research Study of Human Leukocyte Antigen in 13 Cases of Familial Frontal Fibrosing Alopecia: CYP21A2 Gene p.V281L Mutation from Congenital Adrenal Hyperplasia Linked to HLA Class I Haplotype HLA-A33:01; B14:02; C*08:02 as a Genetic Marker

research Alopecia Areata Update

research Alopecia Areata: Pathogenesis, Genetic Factors, and Treatments Using Mouse Models

research Alopecia Areata: Clinical Review and Treatment Approaches

research The Etiology and Pathogenesis of Alopecia Areata

research Human Leukocyte Antigen Class II Alleles Are Associated with Risk of Alopecia Areata

research Alopecia Areata Update

research Genetics of Alopecia

research Organ Specificity in Autoimmune Diseases: Thyroid and Islet Autoimmunity in Alopecia Areata

research Somatostatin Expression in Human Hair Follicles and Its Potential Role in Immune Privilege

research Cell Surface B2m-Free Human Leukocyte Antigen Monomers and Dimers: Are They Neo-HLA Class and Proto-HLA?

research Alopecia Areata: Autoimmune Nature, Genetic Associations, and Treatments

research The Pathogenesis of Alopecia Areata

research Immune Privilege and Alopecia Areata

research Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 NKG2D Lymphocytes in Alopecia Areata Patients

research Genome-Wide Association Study of Alopecia Areata in Taiwan: The Conflict Between Individuals and Hair Follicles

research Alopecia Areata: Clinical Perspective and an Insight into Pathogenesis

research Alopecia Areata After HLA-Identical Bone Marrow Transplant from an Affected Sibling Donor

research Clinical and Genetic Aspects of Alopecia Areata: A Cutting Edge Review

research Alopecia Areata: Genetic and Immunological Insights

research Autoimmunity: Alopecia Areata

research Human FOXN1 Deficiency Is Associated with Alpha Beta Double-Negative and FoxP3 Positive T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation

research Genotyping Of The Rs1800440 Polymorphism In CYP1B1 Gene And The Rs9258883 Polymorphism In HLA-B Gene In A Spanish Cohort Of 223 Patients With Frontal Fibrosing Alopecia

research Epidemiology of Vitiligo, Associated Autoimmune Diseases, and Audiological Abnormalities: Ankara Study of 80 Patients in Turkey

research Genetic Basis of Alopecia Areata

research Lymphocytes, Neuropeptides, And Genes Involved In Alopecia Areata

research A Comparative Analysis of Immune Privilege in Pregnancy and Cancer in the Context of Checkpoint Blockade Immunotherapy

research Identification of Drug-Specific Public TCR Driving Severe Cutaneous Adverse Reactions

research Cutaneous Lupus Erythematosus: Overview and Treatment

research Exomic Sequencing of Immune-Related Genes Reveals Novel Candidate Variants Associated with Alopecia Universalis