Human Leukocyte Antigen Class II Alleles Are Associated with Risk of Alopecia Areata

    July 2007 in “ Journal of Investigative Dermatology ”
    Nazila Barahmani, Mariza de Andrade, Joshua P. Slusser, Peng Han, Maria Hordinsky, Vera H. Price, Angela M. Christiano, David A. Norris, John D. Reveille, Madeleine Duvic
    TLDR Certain HLA class II alleles increase or decrease the risk of alopecia areata.
    The study explored the link between HLA class II alleles and alopecia areata (AA) risk, involving 443 American Caucasian participants, including 99 with persistent patchy AA, 163 with alopecia totalis/universalis (AT/AU), and 152 controls. It confirmed a positive association of the HLA-DQB1*0301 allele with AT/AU and a strong association of the HLA-DRB1*1104 allele with AT/AU risk. Conversely, the HLA-DQB1*0201 allele showed a negative association with AT/AU, indicating a protective effect. These findings suggested that HLA class II alleles were significant in determining susceptibility to AA and could help differentiate AA severity phenotypes.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 1000+ results

      community Alopecia Areata Question

      in Treatment  2 upvotes 3 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

      community mbp alopecia areata or vitamin deficiency

      in Chat 4 months ago
      A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

      community Olumiant alternative for Alopecia Areata?

      in Treatment  1 upvotes 1 year ago
      A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

    Related Research

    2 / 2 results