Human Leukocyte Antigen Class II Alleles Are Associated with Risk of Alopecia Areata

July 2007 in “ Journal of Investigative Dermatology ”

Nazila Barahmani, Mariza de Andrade, Joshua P. Slusser, Peng Han, Maria Hordinsky, Vera H. Price, Angela M. Christiano, David A. Norris, John D. Reveille, Madeleine Duvic

alopecia areata HLA class II alleles HLA-DQB1*0301 HLA-DRB1*1104 alopecia totalis alopecia universalis HLA-DQB1*0201 HLA-DQB1*0202 persistent patchy alopecia areata AA AT AU AAP

This study explored the link between HLA class II alleles and alopecia areata (AA), confirming a positive association of the HLA-DQB1*0301 and HLA-DRB1*1104 alleles with alopecia totalis/universalis (AT/AU), while identifying a protective role for the HLA-DQB1*0201 allele. Additionally, a new positive association was found between the HLA-DQB1*0202 allele and persistent patchy AA (AAP). The research involved 443 genotyped American Caucasian samples, including 99 with AAP, 163 with AT/AU, and 152 controls. These results underscored the genetic complexity of AA and highlighted specific HLA alleles as potential risk and protective factors, suggesting that HLA class II alleles are significant susceptibility determinants for AA. Further studies were recommended to confirm these associations.

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research Genomewide Scan for Linkage Reveals Evidence of Several Susceptibility Loci for Alopecia Areata

143 citations, January 2007 in “The American Journal of Human Genetics”

The study conducted a genomewide search for genetic linkage in 20 families with alopecia areata (AA), involving 102 affected and 118 unaffected individuals from the U.S. and Israel. It identified at least four susceptibility loci on chromosomes 6, 10, 16, and 18, with significant LOD scores on chromosomes 16 and 18. The findings supported previous associations of the human leukocyte antigen locus with AA and suggested that regions on chromosomes 16 and 18 might harbor genes involved in various skin and hair disorders. The study highlighted the complex genetic nature of AA, an autoimmune disorder affecting 1%-2% of the U.S. population, characterized by hair loss and psychological impact.

research Major Histocompatibility Complex Class I Chain-Related Gene A Polymorphisms and Extended Haplotypes Are Associated with Familial Alopecia Areata

44 citations, December 2005 in “Journal of Investigative Dermatology”

Certain genetic markers, especially the MICA gene, are linked to alopecia areata.

research Alopecia Areata: A Tissue-Specific Autoimmune Disease of the Hair Follicle

185 citations, August 2005 in “Autoimmunity Reviews”

Alopecia areata is an autoimmune condition causing hair loss due to the immune system attacking hair follicles, often influenced by genetics and stress.

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research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

April 2019 in “International journal of research in dermatology”

A child with rough nails also had hair loss and allergies.

research Vitiligo After Diphencyprone for Alopecia Areata

18 citations, January 2010 in “Dermatology Research and Practice”

DPCP treatment for alopecia areata can sometimes cause vitiligo.

Human Leukocyte Antigen Class II Alleles Are Associated with Risk of Alopecia Areata

Research cited in this study

research Genomewide Scan for Linkage Reveals Evidence of Several Susceptibility Loci for Alopecia Areata

research Major Histocompatibility Complex Class I Chain-Related Gene A Polymorphisms and Extended Haplotypes Are Associated with Familial Alopecia Areata

research Alopecia Areata: A Tissue-Specific Autoimmune Disease of the Hair Follicle

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