Alopecia Areata: Clinical Perspective and an Insight into Pathogenesis

    April 2003 in “ Journal of dermatology ”
    Virendra Sehgal, Sanjiv Jain
    Image of study
    TLDR Alopecia areata causes hair loss due to an immune attack on hair follicles, influenced by genetics and environment.
    The document provided a comprehensive review of alopecia areata (AA), an autoimmune disorder characterized by localized hair loss. It affected 0.05-0.1% of the population, with a lifetime risk of 1.7%, and involved a T-lymphocyte-mediated attack on hair follicles, influenced by genetic and environmental factors. Histopathological features included peribulbar lymphocytic infiltrate and changes in hair follicle structure. Prognosis varied, with 65% of patients experiencing hair regrowth within 6 months to 2 years. The review highlighted the role of HLA antigens, cytokines, and genetic predisposition in AA, and discussed its association with other autoimmune disorders, potential viral origins, and psychological triggers. Experimental models like C3H/HeJ mice were used to study AA and test treatments, emphasizing the disease's complex pathogenesis and multifactorial triggers.
    Discuss this study in the Community →

    Research cited in this study

    17 / 17 results

    Related Community Posts Join

    6 / 1000+ results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 1 year ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

      community AGA evaluation and first steps - BEGINNER MEGAPOST

      in Chat  81 upvotes 1 year ago
      The conversation discusses androgenic alopecia (AGA) and its treatments, focusing on finasteride, minoxidil, and ketoconazole shampoo. Finasteride is recommended as essential for preventing further hair loss.

      community 17M biotin and minoxidil hair regrowth progress

      in Progress Pictures  83 upvotes 2 years ago
      A user's hair regrowth journey using biotin and minoxidil after initial treatments with Nizoral shampoo and Ketoconazole serum didn't work. The comments suggest the hair loss might not be male pattern baldness (MPB), but possibly Alopecia Areata, an autoimmune disorder, and recommend getting a second opinion and considering other treatments like corticosteroids.

      community To anyone that is still not seeing results on the big 3…

      in Treatment  107 upvotes 3 years ago
      User redh0t12 suggests using a derma pen for hair regrowth, as it helped them after using finasteride and minoxidil. Others discuss their experiences with various treatments, including derma rolling, oral and topical minoxidil, and finasteride, with mixed results.

    Related Research

    1 / 1 results