Genotyping Of The Rs1800440 Polymorphism In CYP1B1 Gene And The Rs9258883 Polymorphism In HLA-B Gene In A Spanish Cohort Of 223 Patients With Frontal Fibrosing Alopecia

September 2023 in “ Acta dermato-venereologica ”

David Saceda‐Corralo, Daniel Ortega‐Quijano, Gloria Muñoz-Martín, Óscar M. Moreno‐Arrones, Cristina Pindado‐Ortega, Tuntas Rayinda, Ana Melián-Olivera, Carlos Azcárraga-Llobet, Patrícia Burgos-Blasco, María Elena Castañeda-Bermúdez, Francisco Castillo, Sergio Vañó‐Galván

frontal fibrosing alopecia rs9258883 polymorphism HLA-B*07:02 allele rs1800440 polymorphism CYP1B1 gene FFA HLA-B CYP1B1

TLDR Certain genetic variants are linked to frontal fibrosing alopecia in Spanish patients.

The study investigated the prevalence of specific genetic polymorphisms in 223 Spanish patients with frontal fibrosing alopecia. It found that 83.8% of patients carried the rs9258883 polymorphism in the HLA-B*07:02 allele, with 58.7% being heterozygous. Additionally, 75.2% of patients lacked the protective rs1800440 polymorphism in the CYP1B1 gene. These findings suggest that these genetic variants play a significant role in the development of frontal fibrosing alopecia and could impact patient prognosis and treatment options.

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research Frontal Fibrosing Alopecia: Demographic and Clinical Characteristics of 490 Cases

53 citations , July 2019 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Frontal fibrosing alopecia mainly affects postmenopausal women and may be linked to thyroid hormones.

research Frontal Fibrosing Alopecia: An Update on Pathogenesis, Diagnosis, and Treatment

61 citations , January 2019 in “American Journal of Clinical Dermatology”

The cause of Frontal Fibrosing Alopecia is unclear, diagnosis involves clinical evaluation and various treatments exist, but their effectiveness is uncertain.

research Study of Human Leukocyte Antigen in 13 Cases of Familial Frontal Fibrosing Alopecia: CYP21A2 Gene p.V281L Mutation from Congenital Adrenal Hyperplasia Linked to HLA Class I Haplotype HLA-A33:01; B14:02; C*08:02 as a Genetic Marker

7 citations , January 2019 in “Australasian Journal of Dermatology”

A genetic marker linked to a type of hair loss was found in most patients studied.

Genotyping Of The Rs1800440 Polymorphism In CYP1B1 Gene And The Rs9258883 Polymorphism In HLA-B Gene In A Spanish Cohort Of 223 Patients With Frontal Fibrosing Alopecia

Cited in this study

research Frontal Fibrosing Alopecia: Demographic and Clinical Characteristics of 490 Cases

research Frontal Fibrosing Alopecia: An Update on Pathogenesis, Diagnosis, and Treatment

research Study of Human Leukocyte Antigen in 13 Cases of Familial Frontal Fibrosing Alopecia: CYP21A2 Gene p.V281L Mutation from Congenital Adrenal Hyperplasia Linked to HLA Class I Haplotype HLA-A33:01; B14:02; C*08:02 as a Genetic Marker

research An Update of the Pathogenesis of Frontal Fibrosing Alopecia: What Does the Current Evidence Tell Us?

research Frontal Fibrosing Alopecia: Reflections and Hypotheses on Etiology and Pathogenesis

research Case Series of Familial Frontal Fibrosing Alopecia and a Review of the Literature

research Postmenopausal Frontal Fibrosing Alopecia: A Frontal Variant of Lichen Planopilaris