Genotyping Of The Rs1800440 Polymorphism In CYP1B1 Gene And The Rs9258883 Polymorphism In HLA-B Gene In A Spanish Cohort Of 223 Patients With Frontal Fibrosing Alopecia

    September 2023 in “ Acta dermato-venereologica ”
    David Saceda‐Corralo, ­Daniel ­Ortega‐Quijano, Gloria Muñoz-Martín, Óscar M. Moreno‐Arrones, Cristina Pindado‐­Ortega, Tuntas Rayinda, Ana Melián-Olivera, Carlos Azcárraga-Llobet, Patrícia Burgos-Blasco, María Elena Castañeda-Bermúdez, Francisco Castillo, Sergio Vañó‐Galván
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    TLDR Certain genetic variants are linked to frontal fibrosing alopecia in Spanish patients.
    The study investigated the prevalence of specific genetic polymorphisms in 223 Spanish patients with frontal fibrosing alopecia. It found that 83.8% of patients carried the rs9258883 polymorphism in the HLA-B*07:02 allele, with 58.7% being heterozygous. Additionally, 75.2% of patients lacked the protective rs1800440 polymorphism in the CYP1B1 gene. These findings suggest that these genetic variants play a significant role in the development of frontal fibrosing alopecia and could impact patient prognosis and treatment options.
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