Frontal Fibrosing Alopecia: Demographic and Clinical Characteristics of 490 Cases

    June 2019 in “ JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology ”
    Varvara Kanti, Andria Constantinou, P. Reygagne, Annika Vogt, Jan Kottner, Ulrike Blume‐Peytavi
    TLDR Frontal fibrosing alopecia mainly affects postmenopausal women and may be linked to thyroid hormones.
    The study on 490 cases of frontal fibrosing alopecia (FFA) revealed that 95% of the patients were female, predominantly postmenopausal. The age of onset ranged from 15 to 89 years, with diagnosis delays up to 24 years. Thyroid disorders were common, affecting 13% of men and 35% of women, while abnormal blood lipid levels were found in 42% of men and 47% of women. Lower disease activity was correlated with abnormal testosterone and estrogen levels, and the use of face cleaning products, hair colorants, and hairspray. The findings suggested a potential role of thyroid hormones in FFA pathogenesis and indicated that leave-on cosmetic products might not contribute to the disease. Further studies were recommended to explore these associations.
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