Genome-Wide Association Study in Frontal Fibrosing Alopecia Identifies Four Susceptibility Loci Including HLA-B*07:02

    March 2019 in “ Nature Communications ”
    Christos Tziotzios, Christos Petridis, Nick Dand, Chrysanthi Ainali, Jake Saklatvala, Venu Pullabhatla, Alexandros Onoufriadis, Rashida Pramanik, David Baudry, Sang Hyuck Lee, Kristie Wood, Lu Liu, Seth Seegobin, Gregory Michelotti, Su M. Lwin, Evangelos Christou, Charles Curtis, Emanuele de Rinaldis, Alka Saxena, Simon Holmes, Matthew Harries, Ioulios Palamaras, Fiona Cunningham, G. Parkins, Manjit Kaur, Paul Farrant, A.J.G. McDonagh, Andrew G. Messenger, Jennifer Jones, Victoria Jolliffe, Iaisha Ali, Michael R. Ardern‐Jones, Charles D. Mitchell, Nigel Burrows, Ravinder Atkar, Cedric C. Banfield, A.B. Alexandroff, Caroline Champagne, Hywel Cooper, Sergio Vañó‐Galván, A.M. Molina‐Ruiz, Nerea Ormaechea Perez, Girish K. Patel, A. E. Macbeth, Melanie C. Page, Alyson Bryden, Megan Mowbray, Shyamal Wahie, Keith Armstrong, Nicola Cooke, Mark Goodfield, Irene Man, David de Berker, Giles Dunnill, Anita Takwale, Archana S. Rao, Tee-Wei Siah, Rodney Sinclair, Martin Wade, Ncoza C. Dlova, Jane Setterfield, Fiona Lewis, Kapil Bhargava, Niall Kirkpatrick, Xavier Estivill, Catherine M. Stefanato, Carsten Flohr, Timothy D. Spector, Fiona M. Watt, Catherine Smith, Juliet N. Barker, David A. Fenton, Michael A. Simpson, John A. McGrath
    TLDR Frontal fibrosing alopecia is linked to four genetic areas, especially the HLA-B*07:02 allele.
    The study investigated the genetic basis of frontal fibrosing alopecia (FFA), a type of hair loss primarily affecting women, through genome-wide association studies involving 844 cases and 3,760 controls from the UK, and 172 cases and 385 controls from Spain. The research identified four genomic loci associated with FFA: 2p22.2, 6p21.1, 8q24.22, and 15q2.1. Notably, the HLA-B*07:02 allele at the 6p21.1 locus was implicated as a significant factor. Additionally, a potential causal variant in the CYP1B1 gene at 2p22.1 was identified. Transcriptomic analysis of affected scalp tissue revealed an overrepresentation of immune response pathways, suggesting that FFA is a genetically predisposed immuno-inflammatory disorder influenced by the HLA-B*07:02 allele.
    Discuss this study in the Community →

    Research cited in this study

    10 / 10 results

    Related Community Posts Join

    6 / 603 results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community 9 months on Fin - no progress , should I get on Dutasteride?

      in Chat  10 upvotes 1 year ago
      The user has been using finasteride, minoxidil, and nizoral for hair loss but hasn't seen regrowth, only maintenance. They are considering switching to dutasteride, which is believed to be more effective, but are concerned about potential side effects.

      community M18 - 7 Months on topical fin + min Not working for me

      in Finasteride/Dutasteride  92 upvotes 9 months ago
      Topical finasteride and minoxidil are not effective for the user, who is considering switching to oral treatments like finasteride or dutasteride. Many suggest oral medications are more effective, and some recommend additional treatments like microneedling and other topical solutions.

      community Testosterone and hair loss seeming irrelevance

      in Research/Science  83 upvotes 2 years ago
      The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

      community Diffuse thinning is so brutal.

      in Styling  70 upvotes 2 years ago
      A 25-year-old with AGA experienced hair thinning and dandruff, stabilized with topical finasteride and minoxidil but saw minimal regrowth. They seek advice on styling and consider oral minoxidil and microneedling for denser hair.

    Similar Research

    5 / 1000+ results