Enhanced Insights Into Frontal Fibrosing Alopecia: Advancements in Pathogenesis Understanding and Management Strategies

    May 2024 in “ Dermatology and Therapy
    Michela Starace, Stephano Cedirian, Luca Rapparini, Federico Quadrelli, Francesca Pampaloni, Francesca Bruni, Bianca Maria Piraccini
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    TLDR Frontal Fibrosing Alopecia needs better diagnostics and treatments, with dutasteride showing promise.
    The document provides a comprehensive analysis of Frontal Fibrosing Alopecia (FFA), a scarring hair loss condition primarily affecting postmenopausal women. It discusses the complex pathogenesis involving genetic, environmental, and inflammatory factors, and highlights the role of PPAR-y and mTOR. Diagnosis is based on clinical, trichoscopic, and histopathologic criteria, with new technologies like reflectance confocal microscopy being explored. Treatment lacks standardization, but topical and systemic therapies, including corticosteroids, calcineurin inhibitors, hydroxychloroquine, and 5-a-reductase inhibitors, show promise. A meta-analysis of 366 patients suggests dutasteride's potential effectiveness. The document emphasizes the need for non-invasive diagnostics and innovative treatments due to FFA's increasing prevalence and calls for further research to improve management strategies.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  821 upvotes 5 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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