Topical Tofacitinib for Patients with Lichen Planopilaris and/or Frontal Fibrosing Alopecia

February 2024 in “ Journal of the American Academy of Dermatology ”

Li-Chi Chen, Chino Ogbutor, Kristen J. Kelley, Maryanne M. Senna

topical tofacitinib JAK-1/3 inhibitor lichen planopilaris frontal fibrosing alopecia cicatricial alopecia oral JAK inhibitors tofacitinib cream

TLDR Topical tofacitinib cream may help treat certain hair loss conditions with fewer risks.

The document discusses the potential of topical tofacitinib, a JAK-1/3 inhibitor, as a treatment for lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA), which are forms of cicatricial alopecia. While oral JAK inhibitors have been used to treat these conditions, they carry risks of serious infections. Topical formulations, such as tofacitinib 2% cream, may offer a safer alternative. The document highlights two cases of women with FFA who showed improvement with this topical treatment, suggesting its potential efficacy with reduced systemic risks.

View this study on jaad.org →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research Tofacitinib for the Treatment of Lichen Planopilaris: A Case Series

79 citations, September 2018 in “Dermatologic therapy”

Oral tofacitinib can significantly improve recalcitrant lichen planopilaris.

Related Community Posts Join

6 / 1000+ results

community What else is good. Besides the big 3.

in Chat 36 upvotes 1 month ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community The shedding caused by Minoxidil is one of the worst things. 2 months apart each picture

in Progress Pictures 290 upvotes 3 months ago

The conversation discusses the severe shedding caused by Minoxidil, with users sharing their experiences and outcomes. Some report eventual regrowth, while others see no improvement or worsening hair loss.

community Finasteride and Oral Minoxidil in Turkey - what I’ve found out

in Finasteride/Dutasteride 9 upvotes 3 months ago

Finasteride is available in Turkey without a prescription, with 1mg tablets costing 800 Turkish lira and 5mg tablets costing 150 lira. Oral minoxidil capsules were found at Cerrahpaşa nur eczanesi, also without a prescription.

community Why not use hair system instead of Topical Hassle

in Hair Systems 20 upvotes 4 days ago

Topical treatments like minoxidil and finasteride are preferred for hair loss due to ease of use and natural appearance. Hair systems are considered high-maintenance and less genuine.

community Why isnt topical fin talked about more?

in Chat 43 upvotes 1 week ago

Topical finasteride is less popular due to inconvenience, cost, and availability, while oral finasteride is favored for ease and safety. Some users experience side effects with topical use, but find it effective with minoxidil, though opinions on its efficacy vary.

community Topical Minoxidil Hyperresponder

in Minoxidil 9 upvotes 3 weeks ago

Minoxidil helped regrow hair from NW3 to NW2 in 5 months despite initial shedding, with additional use of Vitamin D3/K2 on the scalp. Users discuss patience during shedding and the importance of continuing treatments like Minoxidil and Finasteride.

Related Research

2 / 2 results

research Erosive Pustular Dermatosis of the Scalp: Causes and Treatments

13 citations, June 2020 in “International Journal of Dermatology”

A rare scalp condition mainly in older women can be treated with various alternatives to steroids, which may have fewer side effects.

research Off-Label Use of Topical Minoxidil in Alopecia: A Review

32 citations, January 2019 in “American Journal of Clinical Dermatology”

Minoxidil helps treat eyebrow thinning, monilethrix, early hair loss, and shortens chemo-related hair loss.