Topical Tofacitinib for Patients with Lichen Planopilaris and/or Frontal Fibrosing Alopecia

February 2024 in “ Journal of the American Academy of Dermatology ”

Li-Chi Chen, Chino Ogbutor, Kristen J. Kelley, Maryanne M. Senna

topical tofacitinib JAK-1/3 inhibitor lichen planopilaris frontal fibrosing alopecia cicatricial alopecia oral JAK inhibitors tofacitinib cream

TLDR Topical tofacitinib cream may help treat certain hair loss conditions with fewer risks.

The document discusses the potential of topical tofacitinib, a JAK-1/3 inhibitor, as a treatment for lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA), which are forms of cicatricial alopecia. While oral JAK inhibitors have been used to treat these conditions, they carry risks of serious infections. Topical formulations, such as tofacitinib 2% cream, may offer a safer alternative. The document highlights two cases of women with FFA who showed improvement with this topical treatment, suggesting its potential efficacy with reduced systemic risks.

View this study on jaad.org →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research Tofacitinib for the Treatment of Lichen Planopilaris: A Case Series

79 citations, September 2018 in “Dermatologic therapy”

Oral tofacitinib can significantly improve recalcitrant lichen planopilaris.

Related Community Posts Join

6 / 1000+ results

community What else is good. Besides the big 3.

in Chat 36 upvotes 1 month ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community The shedding caused by Minoxidil is one of the worst things. 2 months apart each picture

in Progress Pictures 290 upvotes 2 months ago

The conversation discusses the severe shedding caused by Minoxidil, with users sharing their experiences and outcomes. Some report eventual regrowth, while others see no improvement or worsening hair loss.

community Finasteride and Oral Minoxidil in Turkey - what I’ve found out

in Finasteride/Dutasteride 10 upvotes 2 months ago

Finasteride is available in Turkey without a prescription, with 1mg tablets costing 800 Turkish lira and 5mg tablets costing 150 lira. Oral minoxidil capsules were found at Cerrahpaşa nur eczanesi, also without a prescription.

community Topical Minoxidil Hyperresponder

in Minoxidil 9 upvotes 1 week ago

Minoxidil helped regrow hair from NW3 to NW2 in 5 months despite initial shedding, with additional use of Vitamin D3/K2 on the scalp. Users discuss patience during shedding and the importance of continuing treatments like Minoxidil and Finasteride.

community Topical dutasteride valid success stories

in Finasteride/Dutasteride 1 upvotes 3 weeks ago

Topical dutasteride may not significantly reduce hair loss and could potentially increase testosterone, leading to further hair loss. Users report side effects like mood changes, sleep issues, and severe side effects, with no significant progress in hair regrowth.

community Topical Anti-Androgen users. What are y’all using currently? And what do you believe has the best chance of being approved? Or best results?

in Technology 12 upvotes 3 weeks ago

RU58841 is considered effective by some users, but finasteride and minoxidil are commonly used with varying dosages to manage side effects. Users report different experiences with treatments like pyrilutamide, fluridil, and RU58841, with some seeing results and others not.

Related Research

2 / 2 results

research Erosive Pustular Dermatosis of the Scalp: Causes and Treatments

13 citations, June 2020 in “International Journal of Dermatology”

A rare scalp condition mainly in older women can be treated with various alternatives to steroids, which may have fewer side effects.

research Off-Label Use of Topical Minoxidil in Alopecia: A Review

32 citations, January 2019 in “American Journal of Clinical Dermatology”

Minoxidil helps treat eyebrow thinning, monilethrix, early hair loss, and shortens chemo-related hair loss.