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GlossaryPeroxisome Proliferator-Activated Receptor Gamma (PPAR-y)

nuclear receptor protein regulating genes for fat storage and glucose metabolism

Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) is a type of nuclear receptor protein that regulates the expression of specific genes involved in fat storage, glucose metabolism, and inflammation. It plays a crucial role in the development of adipose tissue and is a target for drugs used to treat conditions like type 2 diabetes and metabolic syndrome.

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Effects of Melatonin Administration on Mental Health Parameters, Metabolic and Genetic Profiles in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

research Effects of Melatonin Administration on Mental Health Parameters, Metabolic and Genetic Profiles in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

45 citations , February 2019 in “Journal of Affective Disorders”

Melatonin improved mental health and metabolism in women with PCOS.

research Influence of Substance P on Cultured Sebocytes

46 citations , April 2008 in “Archives of Dermatological Research”

Substance P may worsen acne by increasing inflammation, but corticosteroids might help by reducing this effect.

research Cicatricial Alopecia: Early Diagnosis and Treatment Strategies

2 citations , January 2015 in “Springer eBooks”

Early diagnosis and aggressive treatment are crucial for Cicatricial Alopecia, and treatment effectiveness varies among patients.

research Cicatricial Alopecia: What's New in Etiology?

November 2015 in “European Journal of Inflammation”

Cicatricial alopecia, a permanent hair loss condition, is mainly caused by damage to specific hair follicle stem cells and abnormal immune responses, with gene regulator PPAR-y and lipid metabolism disorders playing significant roles.

research Folliculocentric Papules and Alopecia in a 70-Year-Old Woman Diagnosed with Graham-Little-Piccardi-Lassueur Syndrome

May 2014 in “Clinical and Experimental Dermatology”

A 70-year-old woman with a rare skin condition improved after treatment with topical steroids and acitretin.

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community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 2 years ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

community Hair Loss & Lipids: Why you have sebderm, folliculitis, LPP, inflammation, etc...

in Research/Science 131 upvotes 11 months ago

Excess sebum rich in cholesterol and triglycerides can lead to hair loss through inflammation, with treatments like Ciclopirox shampoo, Benzoyl Peroxide shampoo, and Clindamycin gel recommended for managing conditions like seborrheic dermatitis and folliculitis. Pioglitazone is suggested for Lichen Planopilaris, while Omega-3s and reducing processed foods may improve sebum quality, though genetic factors play a significant role.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 52 upvotes 1 year ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 44 upvotes 1 year ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

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