Folliculocentric Papules and Alopecia in a 70-Year-Old Woman Diagnosed with Graham-Little-Piccardi-Lassueur Syndrome
May 2014
in “
Clinical and Experimental Dermatology
”
Graham-Little-Piccardi-Lassueur Syndrome lichen planopilaris nonscarring alopecia perifollicular keratotic eruption folliculocentric lymphocytic lichenoid dermatitis high-potency topical steroids systemic corticosteroids ciclosporin doxycycline hydroxychloroquine mycophenolate mofetil acitretin PPAR-y agonists GLPLS LPP topical corticosteroids systemic steroids cyclosporine doxy Plaquenil CellCept Soriatane PPAR-gamma agonists
TLDR A 70-year-old woman with a rare skin condition improved after treatment with topical steroids and acitretin.
A 70-year-old woman was diagnosed with Graham-Little-Piccardi-Lassueur Syndrome (GLPLS), a rare variant of lichen planopilaris (LPP) that presents with a triad of lichen planopilaris of the scalp, nonscarring alopecia of the axillae and pubic area, and a perifollicular keratotic eruption on the body. The patient's symptoms included an itchy rash, hair loss of approximately 25% of scalp hair, and sparse axillary and pubic hair. Initial biopsy suggested lupus erythematosus, but further examination revealed folliculocentric, lymphocytic, lichenoid dermatitis consistent with LPP. Treatment for GLPLS is similar to LPP due to limited data and includes high-potency topical steroids, systemic corticosteroids, ciclosporin, doxycycline, hydroxychloroquine, mycophenolate mofetil, acitretin, and potentially PPAR-y agonists. The patient improved with topical corticosteroids and acitretin treatment. The document emphasizes the rarity of GLPLS, the challenge in its treatment, and the importance of weighing treatment risks against benefits.
