Effects of Melatonin Administration on Mental Health Parameters, Metabolic and Genetic Profiles in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

    February 2019 in “ Journal of Affective Disorders ”
    Azade Shabani, Fatemeh Foroozanfard, Elham Kavossian, Esmat Aghadavod, Vahidreza Ostadmohammadi, Russel J. Reiter, Tahereh Eftekhar, Zatollah Asemi
    Image of study
    TLDR Melatonin improved mental health and metabolism in women with PCOS.
    In a study from 2019 involving 58 women with polycystic ovary syndrome (PCOS), researchers found that a 12-week regimen of 10 mg daily melatonin supplementation significantly improved mental health parameters, including sleep quality, depression, and anxiety scores. It also positively affected metabolic parameters by reducing serum insulin levels, insulin resistance (measured by HOMA-IR), and total and LDL-cholesterol levels, while increasing insulin sensitivity (measured by QUICKI). Furthermore, melatonin was shown to upregulate the gene expression of PPAR-y and LDLR, which are related to insulin and lipid metabolism. These results suggest that melatonin could be a potential therapeutic agent for managing symptoms of PCOS, particularly concerning mental health and metabolic disturbances.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 251 results

      community C’est terrible - at my wits end

      in Female  443 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community Bryan Johnson just dropped his anti hair loss formula

      in Treatment  339 upvotes 9 months ago
      Bryan Johnson shared his hair loss treatment, which mainly relies on minoxidil and finasteride. Some users are skeptical of his results, while others appreciate his efforts in anti-aging and hair loss research.

      community Is anyone using melatonin for hair loss?

      in Research/Science  9 upvotes 5 months ago
      Melatonin is being discussed as a potential treatment for hair loss, with questions about its effectiveness and whether it should be used topically or orally. No specific conclusions or personal experiences were shared.

      community Melatonin options for Europe??? *Retrograde Alopecia*

      in Product  3 upvotes 6 months ago
      A user is considering using melatonin for hair recovery on the side and neck area but is unsure about the best options in Europe and whether a dietary supplement form can be applied to the scalp. They found a product but are hesitant and seeking opinions on its use for alopecia.

      community Optimal dose for topical Melatonin

      in Treatment  6 upvotes 1 year ago
      The conversation is about finding the optimal concentration of topical melatonin for hair loss treatment. The user is considering making their own solution and is unsure whether a higher concentration is more effective for deactivating prolactin receptors.

    Related Research

    1 / 1 results