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research Lipoatrophy and Severe Metabolic Disturbance in Mice with Fat-Specific Deletion of PPARγ

218 citations , October 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

research Non-Clinical Safety Evaluation and Risk Assessment of Aleglitazar, a Dual PPAR α/γ Agonist, and Its Major Human Metabolite

3 citations , March 2017 in “Regulatory toxicology and pharmacology”

Aleglitazar and its major metabolite are safe enough to proceed to Phase 3 clinical trials.

research How to Diagnose a Lipodystrophy Syndrome

53 citations , June 2012 in “Annales d'Endocrinologie”

The document concludes that recognizing and properly diagnosing lipodystrophy syndromes is crucial for effective management and treatment.

research Expression of Peroxisome Proliferator Activated Receptors (PPARs) in Human Hair Follicles and PPARα Involvement in Hair Growth

51 citations , October 2000 in “Acta dermato-venereologica”

PPAR alpha may help in hair growth and could be a target for treatment.

research Influence of Substance P on Cultured Sebocytes

46 citations , April 2008 in “Archives of Dermatological Research”

Substance P may worsen acne by increasing inflammation, but corticosteroids might help by reducing this effect.

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community DHT Oily Scalp Dangers: Theory of an Oily Scalp and PPAR-GAMMA Dysregulation

in Research/Science 32 upvotes 7 months ago

Excessive scalp sebum, worsened by DHT, can lead to inflammation and hair loss, with clascoterone mentioned as a treatment. Diet changes seem ineffective for scalp sebum, and treatments like minoxidil and finasteride are suggested.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

in Research/Science 416 upvotes 6 months ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.

in Research/Science 42 upvotes 9 months ago

ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

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