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research Lipoatrophy and Severe Metabolic Disturbance in Mice with Fat-Specific Deletion of PPARγ

218 citations, October 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

research Non-Clinical Safety Evaluation and Risk Assessment of Aleglitazar, a Dual PPAR α/γ Agonist, and Its Major Human Metabolite

3 citations, March 2017 in “Regulatory toxicology and pharmacology”

Aleglitazar and its major metabolite are safe enough to proceed to Phase 3 clinical trials.

research How to Diagnose a Lipodystrophy Syndrome

53 citations, June 2012 in “Annales d'Endocrinologie”

The document concludes that recognizing and properly diagnosing lipodystrophy syndromes is crucial for effective management and treatment.

research Expression of Peroxisome Proliferator Activated Receptors (PPARs) in Human Hair Follicles and PPARα Involvement in Hair Growth

51 citations, October 2000 in “Acta dermato-venereologica”

PPAR alpha may help in hair growth and could be a target for treatment.

research Influence of Substance P on Cultured Sebocytes

46 citations, April 2008 in “Archives of Dermatological Research”

Substance P may worsen acne by increasing inflammation, but corticosteroids might help by reducing this effect.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 1 year ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

in Research/Science 92 upvotes 2 years ago

The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 47 upvotes 5 months ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 43 upvotes 1 day ago

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