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Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

Aleglitazar and its major metabolite are safe enough to proceed to Phase 3 clinical trials.

The document concludes that recognizing and properly diagnosing lipodystrophy syndromes is crucial for effective management and treatment.

PPAR alpha may help in hair growth and could be a target for treatment.

Substance P may worsen acne by increasing inflammation, but corticosteroids might help by reducing this effect.

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.

Central lipohypertrophy in HIV-infected women may lead to shorter eyelashes.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

SA linked to mitochondrial issues and oxidative stress, while AGA involves disrupted hair growth genes.

Single Blimp1+ cells can create functional sebaceous gland organoids in the lab.

Runx1 controls fat-related genes important for normal and cancer cell growth, affecting skin and hair cell behavior.

Gene therapy shows promise for enhancing physical traits but faces ethical, safety, and regulatory challenges.

Genomic approach finds new possible treatments for hair loss.

31% of female high school students in Minia have hair loss from tight hairstyles, which can become permanent if not treated early.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Astilbin can potentially calm overactive immune responses, like in Type 1 Diabetes, by suppressing certain cell activities and reducing inflammation.

PPARγ is crucial for skin health but can have both beneficial and harmful effects.

PPAR-γ helps control skin oil glands and inflammation, and its disruption can cause hair loss diseases.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

A mother's PPARγ is crucial for preventing harmful milk that can cause inflammation and growth problems in babies.

Lichen Planopilaris and Frontal Fibrosing Alopecia may help us understand hair follicle stem cell disorders and suggest new treatments.

PPAR-γ is important for healthy hair and its problems, and more research on PPAR-γ treatments is needed.

The current understanding of frontal fibrosing alopecia involves immune, genetic, hormonal factors, and possibly environmental triggers, but more research is needed for effective treatments.

PPARγ is essential for maintaining healthy skin, controlling inflammation, and ensuring proper skin barrier function.

Glucosylceramides are essential for healthy skin and proper wound healing.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

New understanding of the causes of primary cicatricial alopecia has led to better diagnosis and potential new treatments.

A specific drug can help treat Lichen Planopilaris, a condition causing permanent hair loss.

Syndecan-1 is essential for maintaining skin fat and preventing cold stress.

Blocking cholesterol production may help control hair loss in Primary Cicatricial Alopecia by affecting key regulators.