Comparative Gene Expression Profiling of Senescent and Androgenetic Alopecia Using Microarray Analysis

This study compared the gene expression profiles of senescent alopecia (SA) and androgenetic alopecia (AGA) using microarray analysis. The results showed that SA is associated with mitochondrial dysfunction and oxidative stress, while AGA is associated with decreased expression of genes required for anagen onset and maintenance and increased expression of catagen and telogen inducers. The study suggests that accumulation of mitochondrial defects in hair stem cells and transient amplifying cells may lead to age-related hair thinning. The authors conclude that further elucidation of mechanisms leading to senescent thinning may provide options for prevention or treatment of hair loss.