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research Macrophage-Stimulating Protein Promotes Hair Growth Ex Vivo and Induces Anagen from Telogen Stage Hair Follicles In Vivo

25 citations , June 2004 in “Journal of Investigative Dermatology”

This study found that macrophage-stimulating protein (MSP) enhanced hair growth in both human hair follicles cultured in vitro and in mice through the promotion of anagen phase induction.

research Topical Application of Oleuropein Induces Anagen Hair Growth in Telogen Mouse Skin

32 citations , June 2015 in “PLOS ONE”

This study demonstrated that topical oleuropein induced hair growth in mice by activating the Wnt10b/β-catenin signaling pathway and increasing expression of several growth-related genes in skin tissue.

research Autophagy induces hair follicle stem cell activation and hair follicle regeneration by regulating glycolysis

January 2024

This study found that activating autophagy in hair follicle stem cells can promote hair growth by shifting their metabolism to glycolysis, while inhibiting it led to delayed hair cycle progression.

research Autophagy induces hair follicle stem cell activation and hair follicle regeneration by regulating glycolysis

June 2023 in “Research Square (Research Square)”

This study found that autophagy activation in hair follicle stem cells shifted their metabolism to glycolysis, which promoted hair growth by initiating the hair follicle cycle.

research Rebamipide Induces Hair Regeneration Through EP4-Driven Lipid Metabolism Remodeling

October 2025 in “International Journal of Molecular Sciences”

This study found that topical rebamipide, originally a gastric ulcer medication, can activate hair follicle stem cells and promote hair regeneration by modulating dermal adipocyte metabolism, with potential targeting of the prostaglandin E receptor EP4.

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Community Join

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community Tretinoin for some men(not all) can cause non-telogen effluvium hair loss

in Research/Science 5 upvotes 1 year ago

Tretinoin can cause non-telogen hair loss in some men by inducing catagen-like changes in hair follicles and through retinoid toxicity, especially when used with minoxidil. Some users report hair loss even when using retinoids on the face, while others experience benefits when combined with treatments like finasteride and minoxidil.

community Hair loss over a year following depression and taking antidepressants

in Side effects? 200 upvotes 8 months ago

A 33-year-old experienced significant hair loss after a depressive episode and taking paroxetine, possibly due to telogen effluvium or androgenic alopecia. Suggestions included reducing alcohol, considering finasteride and minoxidil, and consulting a doctor about antidepressant side effects.

community one month difference, can’t tell if it’s gotten better or wors

in Is this regrowth? 10 upvotes 2 years ago

The user is unsure if their hair has improved or worsened after inconsistent minoxidil use, iron, and vitamin D supplements. A reply suggests the hair looks better but recommends consistent photo angles for accurate comparison.

community PP405 mechanism question - looking for discussion

7 upvotes 5 months ago

PP405 may promote short-term hair growth by pushing follicles into the growth phase, but concerns exist about long-term effects due to lack of rest phases. Users discuss various treatments like finasteride, minoxidil, spironolactone, alfatradiol, and investigational drugs like KX-826 and GT20029 for hair maintenance and regrowth.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

211 upvotes 1 year ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

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Learn

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learn Trichogen® (foligain)

learn Estradiol

an estrogen promoting hair regrowth more commonly used in women

learn Overview

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn KY19382

compound that activates Wnt/β-catenin to promote hair regrowth and create new hair follicles

learn PP405

Got small bald patches they say are from stress? PP405 sprays could help bring them back to life. PP405 is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier; its registered Phase 2 trial (NCT06393452) tested it once daily in 78 adults with pattern hair loss, for safety and tolerability. It is not approved, not for sale, and has not been studied in alopecia areata or stress-related shedding.

learn TDM-105795

How does TDM-105795 differ from more established hair loss ingredients when included in experimental or emerging treatments? TDM-105795 targets thyroid hormone receptors, differing from established treatments like minoxidil and finasteride.
What types of alopecia or hair loss conditions might TDM-105795 be designed to target based on current research? TDM-105795 may target non-scarring alopecia, particularly androgenetic alopecia.

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Clinics

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Hair Systems
Telogen Salon and Hair Restoration CenterHoboken, NJ · US

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