Autophagy Induces Hair Follicle Stem Cell Activation and Hair Follicle Regeneration by Regulating Glycolysis

    June 2023 in “ Research Square (Research Square) ”
    Pingping Sun, Zhan Wang, Sixiao Li … Yong Miao

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that autophagy activation in hair follicle stem cells shifted their metabolism to glycolysis, which promoted hair growth by initiating the hair follicle cycle.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 10

    1. Corticosterone Inhibits GAS6 to Govern Hair Follicle Stem-Cell Quiescence Nature · 2021
    2. Establishment of an Efficient Primary Culture System for Human Hair Follicle Stem Cells Using the Rho-Associated Protein Kinase Inhibitor Y-27632 Frontiers in cell and developmental biology · 2021
    3. Development and Maintenance of Epidermal Stem Cells in Skin Appendages International journal of molecular sciences · 2020
    4. Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle Cell Metabolism · 2020
    5. Stimulation of Hair Growth by Small Molecules That Activate Autophagy Cell reports · 2019
    6. Inactivation of Autophagy Leads to Changes in Sebaceous Gland Morphology and Function Experimental dermatology · 2018
    7. Autophagy Is Essential for Maintaining the Growth of a Human Mini-Organ: Evidence from Scalp Hair Follicle Organ Culture PLOS Biology · 2018
    8. Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation Nature cell biology · 2017
    9. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    10. A Murine Model for Inducing and Manipulating Hair Follicle Regression: Effects of Dexamethasone and Cyclosporin A Journal of Investigative Dermatology · 1994

    Related research 1

    1. Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence Cell reports · 2015