Investigating the Effects of Metabolic Dysregulation on Hair Follicles: A Comparison of HIV-Infected Women With and Without Central Lipohypertrophy

June 2013 in “ International Journal of Dermatology ”

Paradi Mirmirani, Toby Maurer, Mardge H. Cohen, G. D’Souza, Roksana Karim, Michael Plankey, Esther Robison, Anjali Sharma, Phyllis C. Tien, Nancy A. Hessol

metabolic dysregulation hair follicles central lipohypertrophy peripheral lipoatrophy scalp hair texture scalp inflammation eyelash length prostaglandin E2 eyelash follicles

TLDR Central lipohypertrophy in HIV-infected women may lead to shorter eyelashes.

The study investigated the effects of metabolic dysregulation on hair follicles in 1,037 HIV-infected women, focusing on those with central lipohypertrophy. Among 76 women with central lipohypertrophy, there was a significant association with shorter eyelash length (OR 2.3; 95% CI 1.4-3.8) but no changes in scalp hair texture or inflammation. The findings suggested that prostaglandin E2 mediators might influence eyelash follicles, highlighting the need for further research on the link between central obesity and hair disorders in HIV-infected women.

View this study on europepmc.org →

Discuss this study in the Community →

Research cited in this study

15 / 15 results

Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia

research Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia

22 citations, June 2012 in “PLOS ONE”

Cholesterol-related compounds can stop hair growth and cause inflammation in a type of scarring hair loss.

research Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

205 citations, March 2012 in “Science Translational Medicine”

PGD2 stops hair growth and is higher in bald men with AGA.

research Eyelash Growth from Application of Bimatoprost in Gel Suspension to the Base of the Eyelashes

29 citations, May 2010 in “Ophthalmology”

Bimatoprost gel makes eyelashes grow longer, but may cause side effects and should be monitored by an eye doctor.

research Enhancing the Growth of Natural Eyelashes: The Mechanism of Bimatoprost-Induced Eyelash Growth

69 citations, April 2010 in “Dermatologic Surgery”

Bimatoprost is a safe and effective treatment for making eyelashes longer, thicker, and darker.

research Hair Growth Defects in Insig-Deficient Mice Caused by Cholesterol Precursor Accumulation and Reversed by Simvastatin

46 citations, January 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mice lacking Insig proteins had hair growth problems due to cholesterol buildup, but this was fixed by the drug simvastatin.

research Lichen Planopilaris Treated With a Peroxisome Proliferator-Activated Receptor Gamma Agonist

105 citations, December 2009 in “Archives of dermatology”

A specific drug can help treat Lichen Planopilaris, a condition causing permanent hair loss.

research Maternal PPARγ Protects Nursing Neonates by Suppressing the Production of Inflammatory Milk

102 citations, July 2007 in “Genes & Development”

A mother's PPARγ is crucial for preventing harmful milk that can cause inflammation and growth problems in babies.

research Reorganization of Hair Follicles in Human Skin Organ Culture Induced by Cultured Human Follicle-Derived Cells

56 citations, July 2005 in “Experimental Dermatology”

Injected human hair follicle cells can create new, small hair follicles in skin cultures.

research Hair Loss, Insulin Resistance, and Heredity in Middle-Aged Women: A Population-Based Study

49 citations, June 2003 in “European journal of cardiovascular prevention & rehabilitation”

Hair loss in middle-aged women is often linked to insulin resistance and a family history of hair loss, particularly from their fathers.

research Prostaglandin Analogs for Hair Growth: Great Expectations

20 citations, January 2003 in “Dermatology online journal”

Prostaglandin analogs like Latanoprost might help grow hair on the scalp and body.

research Hair and Systemic Disease

58 citations, October 2001 in “Dermatologic Clinics”

Hair loss can indicate underlying systemic diseases and addressing these can sometimes reverse the hair loss.

research Treatment of Hair Loss

370 citations, September 1999 in “The New England Journal of Medicine”

Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.

Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect

research Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect

81 citations, February 1997 in “Journal of Investigative Dermatology”

Minoxidil boosts hair growth by activating PGHS-1.

research Psychological Effects of Androgenetic Alopecia on Women: Comparisons with Balding Men and Female Control Subjects

222 citations, October 1993 in “Journal of The American Academy of Dermatology”

Hair loss affects women's mental health more than men's, causing anxiety, low self-esteem, and social insecurity.

research Testosterone Metabolism in the Skin

74 citations, November 1975 in “Archives of dermatology”

Increased DHT formation in skin can cause hair loss, acne, and excessive hair growth, and antiandrogens might treat these conditions.

Related Community Posts Join

6 / 290 results

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Having androgen receptor density and sensitivity at wrong f*ing place

in Satire 7 upvotes 1 month ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 44 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Bile Acid-Mediated DHT Dysregulation Hypothesis

in Research/Science 13 upvotes 2 weeks ago

Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

community My hair after 3 steroid cycles

in Progress Pictures 25 upvotes 4 months ago

A user shared their hair progress after three steroid cycles, using 5% minoxidil and 100mg RU58841 daily. They are considering a hair transplant due to paranoia about shedding.

community This sub in a nutshell when it comes to medicine. Oral Minoxidil isn’t that bad

in Chat 446 upvotes 1 year ago

The post and conversation are about the use of oral Minoxidil (Min), Finasteride (Fin), and RU58841 for hair loss treatment, with mixed opinions on their safety and effectiveness.

Similar Research

5 / 1000+ results

research Medical and Environmental Risk Factors for the Development of Central Centrifugal Cicatricial Alopecia

88 citations, April 2011 in “Archives of Dermatology”

Type 2 diabetes, bacterial scalp infections, and tight hairstyles like braids and weaves are linked to a higher risk of a scarring hair loss condition in African American women.

research Emerging Nonmetabolic Functions of Skin Fat

65 citations, January 2018 in “Nature Reviews Endocrinology”

Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.

research The Role of Adipocytes in Tissue Regeneration and Stem Cell Niches

42 citations, May 2016 in “Annual Review of Cell and Developmental Biology”

Fat cells are important for tissue repair and stem cell support in various body parts.

research PKC Downregulation Upon Rapamycin Treatment Attenuates Mitochondrial Disease

26 citations, December 2020 in “Nature metabolism”

Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.

research A Review and Meta-Analysis of the Prevalence and Health Impact of Polycystic Ovary Syndrome Among Medical and Dental Students

1 citations, June 2023 in “Curēus”

PCOS affects nearly 25% of female medical and dental students, impacting their academic and social lives.