Investigation of the Role of SIRT3, SIRT7, NFATC1, and PDL-1 Genes in Androgenetic Alopecia

    November 2024 in “ BMC Research Notes
    Hadis Abbasian, Mehrdad Noruzinia, Masoud Garshasbi
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    This study investigates the role of SIRT3, SIRT7, NFATC1, and PDL-1 genes in androgenetic alopecia (AGA), focusing on their expression patterns during hair follicle aging. Researchers analyzed mesenchymal stem cells from six men with AGA, finding that SIRT3 and SIRT7 expression levels, which typically decrease with hair follicle aging, were also reduced in AGA samples. Conversely, NFATC1 and PDL-1, which usually increase with aging, were elevated in AGA samples. Bioinformatic analyses support the involvement of SIRT3, SIRT7, and NFATC1 in AGA pathogenesis. While SIRT3 and SIRT7 are suggested to play critical roles in AGA development, further research is needed to understand the significance of NFATC1 and PDL-1 and their potential as therapeutic targets.
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