Integrated Multi-Omics Analysis Reveals Dysregulated Lipid Metabolism as a Novel Mechanism in Androgenetic Alopecia

    January 2026 in “ Biomedicines ”
    Xiao‐Shuang Yang, Liyang Duan, Yu-Jie Miao … Ru Dai
    Studysummary This study identified increased expression of ACAA1 and its regulation by hsa-miR-1343-3p, linking androgenetic alopecia to lipid metabolism pathways, particularly through PPAR signaling, in scalp tissues.
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    Research cited in this study 16

    1. S100A8 Induces Cyclophosphamide-Induced Alopecia via NCF2/NOX2-Mediated Ferroptosis Free Radical Biology and Medicine · 2025
    2. Androgenic Alopecia Is Associated With Higher Dietary Inflammatory Index And Lower Antioxidant Index Scores Frontiers in Nutrition · 2024
    3. Factors Associated With Early-Onset Androgenetic Alopecia: A Scoping Review PLOS ONE · 2024
    4. The Biology and Genomics of Human Hair Follicles: A Focus on Androgenetic Alopecia International Journal of Molecular Sciences · 2024
    5. Serum Lipidomic Changes and Sex Differences in Androgenetic Alopecia Heliyon · 2024
    6. Deciphering the Molecular Mechanisms of Stem Cell Dynamics in Hair Follicle Regeneration 2024
    7. Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche Nature Reviews Molecular Cell Biology · 2023
    8. SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes Advanced science · 2022
    9. Systematic Review and Meta-Analysis of the Association Between Metabolic Syndrome and Androgenetic Alopecia Acta dermato-venereologica · 2021
    10. PPAR-γ Signaling as a Key Mediator of Human Hair Follicle Physiology and Pathology Experimental Dermatology · 2019
    11. Cholesterol Homeostasis: Links to Hair Follicle Biology and Hair Disorders Experimental Dermatology · 2019
    12. Progressive Expression of PPARGC1α Is Associated with Hair Miniaturization in Androgenetic Alopecia Scientific Reports · 2019
    13. Hair Growth Cycle Is Arrested in SCD1 Deficiency by Impaired Wnt3a-Palmitoleoylation and Retrieved by the Artificial Lipid Barrier Journal of Investigative Dermatology · 2017
    14. Lipid Profile in Patients with Androgenetic Alopecia: A Meta-Analysis Journal of The European Academy of Dermatology and Venereology · 2016
    15. Global Photographic Assessment of Men Aged 18 to 60 Years with Male Pattern Hair Loss Receiving Finasteride 1 mg or Placebo Journal of The American Academy of Dermatology · 2012
    16. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010