Multiomics-Empowered Deep Phenotyping of Ulcerative Colitis Identifies Biomarker Signatures Reporting Functional Remission States

    March 2023 in “ Journal of Crohn s and Colitis ”
    Lukas Janker, Dina Schuster, Patricia Bortel, Gerhard Hagn, Samuel M. Meier, Thomas Mohr, Johanna C. Mader, Astrid Slany, Andrea Bileck, Julia Brunmair, Christian Madl, Lukas Unger, Barbara Hennlich, Barbara Weitmayr, Giorgia Del Favero, Dietmar Pils, Tobias Pukrop, Nikolaus Pfisterer, T Feichtenschlager, Christopher Gerner
    TLDR Microvascular damage and platelet issues persist in ulcerative colitis remission, helping assess disease states.
    The study on ulcerative colitis (UC) suggests that microvascular damage and platelet deregulation persist even during remission, serving as disease-associated molecular signatures. It integrates local and systemic molecular alterations into a model for UC pathomechanisms, which could aid in assessing disease and remission states in UC patients.
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