DUPA - Impossible to cure, so giving up
    Update 9/18/2025

    From the encyclopedia
    Dutasteride →

    Heavy duty finasteride that comes with higher risks

    Finasteride →

    Frontline, gold standard treatment for combatting androgenic alopecia

    RU58841 →

    a potent but unapproved and potentially problematic topical anti-androgen

    At a glance
    In this treatment experience post, the primary subjects mentioned are
    💊 Dutasteride (oral) over a year
    💊 Finasteride (oral) over a year
    💧 RU58841 (topical) over a year
    💧 Minoxidil (topical) over a year
    the tone is 😞 negative with no change in hair loss results.

    Other terms

    The user diagnosed with DUPA tried treatments like dutasteride, finasteride, RU58841, and minoxidil without success and is considering a hair system. They hope for a future cure, possibly with PP405, and others suggest options like scalp biopsy and SMP.
    View this post in the Community →

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      community DUPA hitting me in my 30s despite fin + min - Looking for options

      in Basic Questions  310 upvotes 3 weeks ago
      A 32-year-old experiencing diffuse hair loss despite long-term use of finasteride and oral minoxidil is considering additional treatments like topical dutasteride, RU58841, and Breezula. Concerns about Crohn's disease affecting hair loss and past negative experiences with dutasteride impacting libido are also mentioned.

      community RU58841 is the only thing that worked for me, a DUPA sufferer

      in Treatment  1 upvotes 1 year ago
      RU58841 was the only treatment that slowed hair loss and reduced irritation for a DUPA sufferer after trying finasteride, minoxidil, and dutasteride with no success. The user continues using 6mg oral minoxidil, 0.5mg dutasteride, and an 8% RU58841 solution.

      community DUPA - 20 YO - Non responder to everything

      in Finasteride/Dutasteride  13 upvotes 2 years ago
      A 20-year-old user experienced worsening hair loss despite using various treatments including topical and oral minoxidil, finasteride, and dutasteride. Other users suggested additional treatments like JAK inhibitors, RU58841, and lifestyle changes, but the user remains skeptical and frustrated.

      community 1year Fin -> 1 year DUT + oral Minox; No results :(

      in Finasteride/Dutasteride  41 upvotes 2 months ago
      The user tried finasteride, dutasteride, and oral minoxidil for hair loss with no success and was diagnosed with androgenetic alopecia. They are considering increasing dosages and trying other treatments like RU58841, GHK-CU, and clascoterone, while seeking further medical opinions.

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