Serum Lipidomic Changes and Sex Differences in Androgenetic Alopecia

February 2024 in “ Heliyon ”

Shuqin Wang, Mei Li, Shichun Qin, Rui Wang, Lei Dong, Sheng Wang, Feng‐Li Xiao

androgenetic alopecia lipid metabolism triglycerides phospholipids sphingolipids biomarkers dihydrotestosterone prostaglandin D2 transforming growth factor-β1 metabolic syndrome AGA DHT PGD2 TGF-β1

TLDR People with androgenetic alopecia have different lipid levels in their blood, which vary between men and women, and may be linked to a higher risk of metabolic syndrome.

The study involving 83 patients with androgenetic alopecia (AGA) and 84 healthy controls found significant differences in lipid metabolism between the two groups. Fifty-one lipids showed significant changes, with seven triglycerides upregulated and 44 lipids, including phospholipids and sphingolipids, downregulated. These seven lipids could serve as potential biomarkers for AGA. The study also found sex differences in AGA lipid metabolites, with 42 differential lipid metabolites identified in male AGA and 81 in female AGA. Thirteen lipid metabolites were unique to male AGA patients, 52 were unique to female AGA patients, and 29 were shared by both sexes. The levels of dihydrotestosterone (DHT), prostaglandin D2 (PGD2), and transforming growth factor-β1 (TGF-β1) were significantly elevated in AGA patients and showed correlations with these lipids. AGA patients were also more prone to developing metabolic syndrome.

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