Circulating and/or Cutaneous Irisin Resistance: A Novel Link Among Androgenetic Alopecia, Comorbid Metabolic Syndrome and Cardiovascular Risks

    May 2023 in “ Journal of Cosmetic Dermatology ”
    Noha Mohammed Dawoud, Marwa M. Dawoud, Sally M. El Hefnawy … Iman Seleit
    Studysummary This study found that AGA patients had higher serum and epidermal irisin levels, which were associated with metabolic syndrome, dyslipidemia, and abnormal carotid intima media thickness, suggesting potential irisin resistance affecting cardiometabolic health.
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    Research cited in this study 7

    1. Severe Androgenetic Alopecia as a Marker of Metabolic Syndrome in Male Patients: A Hospital-Based Case Control Study International Journal of Research in Medical Sciences · 2017
    2. Classification and Scoring of Androgenetic Alopecia (Male and Female Pattern) Springer eBooks · 2017
    3. Alopecia and Its Association with Coronary Heart Disease and Cardiovascular Risk Factors: A Meta-Analysis International Journal of Cardiology · 2014
    4. Androgenetic Alopecia Is Associated With Increased Arterial Stiffness in Asymptomatic Young Adults Journal of The European Academy of Dermatology and Venereology · 2014
    5. Androgenetic Alopecia and Cardiovascular Risk Factors in Men and Women: A Comparative Study Journal of The American Academy of Dermatology · 2010
    6. Association of Androgenetic Alopecia with Metabolic Syndrome in Men: A Community-Based Survey British Journal of Dermatology · 2010
    7. Androgenetic Alopecia in Men and Women Clinics in Dermatology · 2001