Serum Irisin Level in Patients with Acne Vulgaris

January 2024 in “ International Journal of Dermatology Venereology and Leprosy Sciences ”

Nader Ibrahim, Nashwa N. Elfar, Manal El‐Batch, Basma Mourad Mohammed Ali

acne vulgaris hair follicles sebaceous glands comedones inflammatory lesions insulin resistance serum irisin thermogenesis subcutaneous adipose tissue acne pimples zits skin inflammation fat tissue

TLDR Patients with acne vulgaris have lower serum irisin levels.

The study investigates the serum irisin levels in patients with acne vulgaris, a common inflammatory skin condition affecting hair follicles and sebaceous glands. Acne vulgaris is characterized by comedones and inflammatory lesions on the face, chest, shoulders, and back. Insulin resistance, which decreases cell sensitivity to insulin, is linked to various skin conditions, including acne vulgaris. Irisin, a hormone associated with body size, shape, and obesity, can improve insulin resistance by stimulating thermogenesis and energy consumption in subcutaneous adipose tissue. The intervention in the study led to decreased glucose and insulin levels, indicating improved insulin resistance.

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Research cited in this study

5 / 5 results

research Serum Irisin: A Prognostic Marker for Severe Acne Vulgaris

8 citations , September 2018 in “Journal of Cosmetic Dermatology”

Lower irisin levels in the blood may indicate more severe acne.

research Acne as a Chronic Systemic Disease

71 citations , November 2013 in “Clinics in Dermatology”

Acne is a chronic disease linked to various systemic conditions and has significant psychological and social effects.

research Acne Severity and the Global Acne Grading System in Polycystic Ovary Syndrome

22 citations , August 2013 in “International journal of gynaecology and obstetrics”

Acne severity in women with PCOS is linked to younger age, lower body weight, and more body hair, but not to hormone levels.

research Role of Insulin Resistance and Diet in Acne

39 citations , January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

Eating high glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.

research Acne-Associated Syndromes: Models for Better Understanding of Acne Pathogenesis

99 citations , December 2010 in “Journal of The European Academy of Dermatology and Venereology”

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

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