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This study found that AGA patients had higher serum and epidermal irisin levels, which were associated with metabolic syndrome, dyslipidemia, and abnormal carotid intima media thickness, suggesting potential irisin resistance affecting cardiometabolic health.

In this study, researchers found that women with PCOS and insulin resistance had higher irisin levels, while both PCOS groups had lower betatrophin levels compared to controls. These distinct biomarker alterations could aid in better metabolic profiling and risk assessment for PCOS.

This study found that serum irisin levels were significantly lower in patients with androgenetic alopecia compared to healthy controls, but no significant relationship was detected between serum irisin levels and insulin resistance markers like BMI, fasting insulin, or HOMA-IR.

This study found that serum irisin levels were significantly lower in patients with acne vulgaris compared to healthy controls and were negatively correlated with insulin resistance and disease severity.

This study reports that an intervention decreased glucose and insulin levels, indicating improved insulin resistance, which is linked to a skin condition called acne vulgaris and other disorders associated with insulin resistance.