TLDR Lower serum irisin levels are linked to androgenetic alopecia but not to insulin resistance.
This study evaluated serum irisin levels in 65 patients with androgenetic alopecia (AGA) compared to 64 healthy controls, finding that AGA patients had significantly lower serum irisin levels. A serum irisin level of ≤10.5 ng/mL could perfectly distinguish between AGA patients and controls with 100% sensitivity and specificity. However, no significant correlation was found between serum irisin levels and insulin resistance markers such as BMI, fasting insulin, or HOMA-IR. These findings suggest that while serum irisin is lower in AGA patients, it does not correlate with insulin resistance, indicating its potential role in the pathogenesis of AGA rather than in metabolic syndrome.
52 citations
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February 2018 in “Diabetology & Metabolic Syndrome” Some skin conditions may indicate metabolic syndrome, which could help with early detection and management of related health issues.
14 citations
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January 2018 in “Advances in Clinical Chemistry” The document concludes that hormonal biomarkers are key for diagnosing hyperandrogenemia in women and hypogonadism in men.
6 citations
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July 2019 in “Children (Basel)” The review concludes that more research is needed to better improve the health outcomes for people with Polycystic Ovarian Syndrome.
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April 2016 in “Journal of the Formosan Medical Association” Metformin improved insulin resistance and BMI in overweight Taiwanese women with PCOS, and a 2-hour insulin test may be a good screening tool.
