Brown Adipose Tissue and Novel Management Strategies for Polycystic Ovary Syndrome Therapy

The document reviewed the potential of brown adipose tissue (BAT) as a therapeutic target for polycystic ovary syndrome (PCOS), a complex disorder affecting reproductive-age women. BAT plays a crucial role in metabolism and energy expenditure, and its activation could regulate PCOS features by affecting energy balance and glucose and lipid homeostasis. The review highlighted various strategies, such as cold stimulation, BAT transplantation, and compound activation, which showed effectiveness in animal models for increasing BAT mass or activity. The findings suggested that BAT could be a novel management strategy for improving women's health with PCOS, emphasizing the importance of identifying key brown adipokines for developing new therapeutic candidates.