Unraveling the Link Between Insulin Resistance and Androgen Excess

    Michael O’Reilly
    Studysummary This study showed that regulation of adipose androgen generation via AKR1C3 may contribute to a cycle of hyperinsulinaemia and lipid accumulation in women with PCOS.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 25

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    2. Polycystic Ovary Syndrome: A Review for Dermatologists Journal of the American Academy of Dermatology · 2014
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    4. Global Adiposity and Thickness of Intraperitoneal and Mesenteric Adipose Tissue Depots Are Increased in Women With Polycystic Ovary Syndrome The Journal of Clinical Endocrinology and Metabolism · 2013
    5. Evidence for Masculinization of Adipokine Gene Expression in Visceral and Subcutaneous Adipose Tissue of Obese Women With Polycystic Ovary Syndrome The Journal of Clinical Endocrinology and Metabolism · 2013
    6. Diabetes and Cardiovascular Events in Women with Polycystic Ovary Syndrome: A 20-Year Retrospective Cohort Study Clinical Endocrinology · 2012
    7. Influence of Spironolactone Treatment on Endothelial Function in Non-Obese Women with Polycystic Ovary Syndrome European Journal of Endocrinology · 2011
    8. Visually Scoring Hirsutism Human reproduction update · 2009
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    10. Global Adiposity Rather Than Abnormal Regional Fat Distribution Characterizes Women with Polycystic Ovary Syndrome The Journal of Clinical Endocrinology and Metabolism · 2007
    11. The Diagnosis of Polycystic Ovary Syndrome: The Criteria Are Insufficiently Robust for Clinical Research Clinical Endocrinology · 2007
    12. Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline The Journal of Clinical Endocrinology and Metabolism · 2006
    13. Excess Salt And Pepper Hair Treated With A Combination Of Laser Hair Removal And Topical Eflornithine HCl PubMed · 2006
    14. Health Care-Related Economic Burden of Polycystic Ovary Syndrome During the Reproductive Life Span The Journal of Clinical Endocrinology and Metabolism · 2005
    15. Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome Fertility and Sterility · 2004
    16. Endocrine and Intracrine Sources of Androgens in Women: Inhibition of Breast Cancer and Other Roles of Androgens and Their Precursor Dehydroepiandrosterone Endocrine Reviews · 2003
    17. 5α-Reductase and 11β-Hydroxysteroid Dehydrogenase Activity in Prepubertal Hispanic Girls with Premature Adrenarche The Journal of Clinical Endocrinology & Metabolism · 2002
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    19. Comparison of Spironolactone, Flutamide, and Finasteride Efficacy in the Treatment of Hirsutism: A Randomized, Double-Blind, Placebo-Controlled Trial The Journal of Clinical Endocrinology and Metabolism · 2000
    20. Prevalence of Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study The Journal of Clinical Endocrinology and Metabolism · 1998
    21. Leuprolide and Estrogen Versus Oral Contraceptive Pills for the Treatment of Hirsutism: A Prospective Randomized Study The Journal of Clinical Endocrinology & Metabolism · 1995
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    23. Effect of Leuprolide and Dexamethasone on Hair Growth and Hormone Levels in Hirsute Women: The Relative Importance of the Ovary and the Adrenal in the Pathogenesis of Hirsutism The Journal of Clinical Endocrinology & Metabolism · 1990
    24. Insulin Administration Alters Gonadal Steroid Metabolism Independent of Changes in Gonadotropin Secretion in Insulin-Resistant Women with Polycystic Ovary Syndrome Journal of Clinical Investigation · 1989
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