Comparison of Spironolactone, Flutamide, and Finasteride Efficacy in the Treatment of Hirsutism: A Randomized, Double-Blind, Placebo-Controlled Trial

    January 2000 in “ The Journal of Clinical Endocrinology and Metabolism ”
    Paolo Moghetti, Flavia Tosi, Antonella Tosti … Roberto Castello
    Studysummary This study found that spironolactone, flutamide, and finasteride are similarly effective in reducing hair diameter and Ferriman-Gallwey scores in women with hirsutism over a 6-month treatment period.
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    Research cited in this study 17

    1. Comparison of Finasteride Versus Spironolactone in the Treatment of Idiopathic Hirsutism Fertility and Sterility · 1997
    2. Successful Treatment of Hirsutism in HAIR-AN Syndrome Using Flutamide, Spironolactone, and Birth Control Therapy Archives of dermatology · 1997
    3. The Clinical Management of Hirsutism European journal of endocrinology · 1997
    4. Treatment of Hirsutism by Finasteride and Flutamide in Women with Polycystic Ovary Syndrome Gynecological Endocrinology · 1997
    5. Outcome of Long-Term Treatment with the 5α-Reductase Inhibitor Finasteride in Idiopathic Hirsutism: Clinical and Hormonal Effects During a 1-Year Course of Therapy and 1-Year Follow-Up Fertility and Sterility · 1996
    6. Leuprolide and Estrogen Versus Oral Contraceptive Pills for the Treatment of Hirsutism: A Prospective Randomized Study The Journal of Clinical Endocrinology & Metabolism · 1995
    7. Clinical Review 73: Medical Treatment of Androgen-Dependent Hirsutism ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 1995
    8. A Prospective Randomized Trial Comparing Finasteride to Spironolactone in the Treatment of Hirsute Women The Journal of Clinical Endocrinology and Metabolism · 1995
    9. Clinical and Hormonal Effects of the 5 Alpha-Reductase Inhibitor Finasteride in Idiopathic Hirsutism The Journal of Clinical Endocrinology and Metabolism · 1994
    10. The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness The Journal of Clinical Endocrinology and Metabolism · 1994
    11. Comparison of Flutamide and Spironolactone in the Treatment of Hirsutism: A Randomized Controlled Trial Fertility and Sterility · 1994
    12. Hepatotoxicity Complicating Flutamide Treatment of Hirsutism Annals of internal medicine · 1993
    13. Flutamide in the Treatment of Hirsutism International journal of gynaecology and obstetrics · 1991
    14. Comparison of Sequential Cyproterone Acetate/Estrogen Versus Spironolactone/Oral Contraceptive in the Treatment of Hirsutism ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 1991
    15. Treatment of Hirsutism with the Pure Antiandrogen Flutamide Journal of the American Academy of Dermatology · 1990
    16. The Effects of Two Doses of Spironolactone on Serum Androgens and Anagen Hair in Hirsute Women Fertility and sterility · 1985
    17. Pharmacology and Potential Use of Cyproterone Acetate Hormone and metabolic research · 1977

    Related research 12

    1. Spironolactone Versus Placebo or in Combination with Steroids for Hirsutism and/or Acne Cochrane library · 2009
    2. Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline The Journal of Clinical Endocrinology & Metabolism · 2008
    3. Antiandrogens for the Treatment of Hirsutism: A Systematic Review and Meta-Analyses of Randomized Controlled Trials ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2008
    4. Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline The Journal of Clinical Endocrinology and Metabolism · 2006
    5. Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome Fertility and Sterility · 2004
    6. Comparison of Diane 35 and Diane 35 Plus Finasteride in the Treatment of Hirsutism Fertility and Sterility · 2001
    7. Comparison of Finasteride Versus Flutamide in the Treatment of Hirsutism European journal of endocrinology · 1999
    8. A Prospective Randomized Trial Comparing Low Dose Flutamide, Finasteride, Ketoconazole, and Cyproterone Acetate-Estrogen Regimens in the Treatment of Hirsutism The Journal of Clinical Endocrinology and Metabolism · 1999
    9. Treatment of Hirsutism: Comparisons Between Different Antiandrogens with Central and Peripheral Effects Fertility and sterility · 1999
    10. Prevalence of Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study The Journal of Clinical Endocrinology and Metabolism · 1998
    11. A Prospective Randomized Trial Comparing Finasteride to Spironolactone in the Treatment of Hirsute Women The Journal of Clinical Endocrinology and Metabolism · 1995
    12. Comparison of Flutamide and Spironolactone in the Treatment of Hirsutism: A Randomized Controlled Trial Fertility and Sterility · 1994