Comparison of Spironolactone, Flutamide, and Finasteride Efficacy in the Treatment of Hirsutism: A Randomized, Double-Blind, Placebo-Controlled Trial

    January 2000 in “ The Journal of Clinical Endocrinology and Metabolism ”
    Paolo Moghetti, Flavia Tosi, Antonella Tosti, Carlo Negri, Cosimo Misciali, Fabrizia Perrone, Marco Caputo, Michele Muggeo, Roberto Castello
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    TLDR Spironolactone most effective for hirsutism, but has side effects.
    This study compared the effectiveness of spironolactone, flutamide, finasteride, and a placebo in treating hirsutism in women. Spironolactone and flutamide were found to be more effective than finasteride and placebo in reducing hirsutism, but spironolactone had more side effects. The study involved 40-134 women and lasted for 6 months. Overall, spironolactone was found to be the most effective treatment for hirsutism, but its side effects should be considered.
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