Flutamide in the Treatment of Hirsutism

October 1991 in “ International journal of gynaecology and obstetrics ”

Tiziano Motta, Giovanni Maggi, Maria Teresa Perra, E. Azzolari, S Casazza, A D’Alberton

flutamide hirsutism Ferriman and Gallwey hair score androstenedione acne seborrhea antiandrogenic properties

TLDR Flutamide effectively reduces hair growth in women with hirsutism and improves acne and seborrhea without side effects.

In a study conducted by T. Motta and colleagues, ten hirsute women were treated with flutamide (250 mg/day) for 6 months to assess its efficacy. The treatment significantly reduced hair growth as measured by the Ferriman and Gallwey hair score (P < 0.01). Additionally, there was a notable increase in serum androstenedione levels (P < 0.01), and marked improvements in acne and seborrhea were observed. No side effects were reported during the treatment period. The findings suggested that flutamide's antiandrogenic properties made it a suitable single agent for treating hirsutism.

View this study on obgyn.onlinelibrary.wiley.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 21 results

community Any balding females? I need advice with coping :(

16 upvotes 8 years ago

A 27-year-old woman is struggling with hair loss, feeling self-conscious and seeking advice on coping. She mentions trying Minoxidil but is hesitant due to scalp issues and is looking for ways to regain confidence.

community I am having Success with RU58841 and 1mm Derma Roller

in Microneedling 19 upvotes 2 years ago

A user reported success with RU58841 and a 1mm derma roller for hair regrowth, noting significant improvement in hair density and reduced scalp visibility. They also mentioned using minoxidil and black castor oil in the past, with mixed results.

community Monthly Reminder.

8 upvotes 6 years ago

Various treatments for male pattern baldness including Minoxidil, Finasteride/Dutasteride, hair systems, and oral anti-androgens such as Spironolactone and Flutamide. It also mentions dermarolling as a possible treatment in conjunction with minoxidil.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 1 year ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

community Everyone seems to be looking for an antiandrogen as an add on. But what about Estradiol & its derivatives ( excluding the low concentraion alfatradiool ) being used. Anyone has an experience with this ? Anything that won't cause feminization in the process ?

in Chat 6 upvotes 2 months ago

The conversation discusses using estradiol and its derivatives for hair loss without causing feminization. Users mention alternatives like alfatradiol, topical 17b-Estradiol, and DIM (Diindolylmethane).

community Are these all the anti androgen products?

in Treatment 6 upvotes 1 year ago

The conversation lists hair loss treatments including finasteride, dutasteride, RU58841, pyrilutamide, breezula, and fluridil, and suggests ketoconazole as another option. Some users warn against using certain treatments like cyproterone acetate, bicalutamide, and spironolactone due to their strong anti-androgen effects and potential impact on masculinity.

Related Research

4 / 4 results

research Finasteride And Flutamide In The Treatment Of Hirsutism

1 citations, October 1997 in “PubMed”

Finasteride and flutamide can effectively treat hirsutism, with abdominal hairs showing the most sensitivity to the treatment.

Clinical Efficacy and Safety of Low-Dose Flutamide Alone and Combined with an Oral Contraceptive for the Treatment of Idiopathic Hirsutism

research Clinical Efficacy and Safety of Low-Dose Flutamide Alone and Combined with an Oral Contraceptive for the Treatment of Idiopathic Hirsutism

36 citations, November 1995 in “Clinical endocrinology”

Low-dose flutamide helps reduce excessive hair growth and is even more effective with birth control, without bad effects on blood fats.

research Comparison of Flutamide and Spironolactone in the Treatment of Hirsutism: A Randomized Controlled Trial

165 citations, February 1994 in “Fertility and Sterility”

Flutamide is more effective and has fewer side effects than spironolactone for treating hirsutism.

research Treatment of Hirsutism with the Pure Antiandrogen Flutamide

130 citations, September 1990 in “Journal of the American Academy of Dermatology”

Flutamide effectively reduced excessive hair growth and improved related symptoms in hirsutism patients without significant side effects.