Successful Treatment of Hirsutism in HAIR-AN Syndrome Using Flutamide, Spironolactone, and Birth Control Therapy

The document reports the case of a 15-year-old obese Mexican girl who sought treatment for hirsutism, which had caused her significant social and psychological distress. She exhibited high insulin levels of 359 pmol/L and elevated free testosterone levels of 29.8 nmol/L, but other hormone levels and tests were normal. The therapeutic goal was to improve her hirsutism to allow her to return to social activities without psychological trauma. The patient was treated with flutamide (125 mg), spironolactone, and birth control therapy, although the document does not provide the outcomes of this treatment or the duration of the therapy. The document is dated from 1997, and therefore the treatment outcomes and current relevance of the therapy are not provided in the summary.